Multi-gene panel testing increases germline predisposing mutations’ detection in a cohort of breast/ovarian cancer patients from Southern Italy
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Medicine"
DOI: 10.3389/fmed.2022.894358
Abstract: Breast cancer is the most common neoplasia in females worldwide, about 10% being hereditary/familial and due to DNA variants in cancer-predisposing genes, such as the highly penetrant BRCA1/BRCA2 genes. However, their variants explain up to… read more here.
Keywords: hereditary familial; breast; panel; gene ... See more keywords
Somatic Mutation Profiling in the Liquid Biopsy and Clinical Analysis of Hereditary and Familial Pancreatic Cancer Cases Reveals KRAS Negativity and a Longer Overall Survival
Sign Up to like & getrecommendations! Published in 2021 at "Cancers"
DOI: 10.3390/cancers13071612
Abstract: Simple Summary Pancreatic ductal adenocarcinoma (PDAC) has a poor prognosis. KRAS mutations occur in up to 95% of cases and render the tumor resistant to many types of therapy. Therefore, these patients are treated with… read more here.
Keywords: familial pancreatic; pancreatic cancer; hereditary familial; overall survival ... See more keywords
Hereditary vs Familial Pancreatic Cancer: Associated Genetic Syndromes and Clinical Perspective.
Sign Up to like & getrecommendations! Published in 2020 at "Oncology"
DOI: 10.46883/onc.3406.0196
Abstract: Pancreatic ductal adenocarcinoma (PDAC) is a disease marked by high rates of mortality; it is mostly incurable at the time of diagnosis. Only about 7% of patients survive 5 years after diagnosis. Diagnosis at a… read more here.
Keywords: familial pancreatic; pancreatic cancer; hereditary familial; cancer ... See more keywords