A transgenic mouse model reproduces human hereditary systemic amyloidosis.
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DOI: 10.1016/j.kint.2019.03.013
Abstract: Amyloidoses are rare life-threatening diseases caused by protein misfolding of normally soluble proteins. The fatal outcome is predominantly due to renal failure and/or cardiac dysfunction. Because amyloid fibrils formed by all amyloidogenic proteins share structural… read more here.
Keywords: mice; mouse model; hereditary systemic; systemic amyloidosis ... See more keywords