Revised prevalence estimate of possible Hereditary Xerocytosis as derived from a large U.S. Laboratory database
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DOI: 10.1002/ajh.24923
Abstract: SCD to prevent irreversible cardiac involvement. Figure 1B shows the algorithm that we follow at our institution for the diagnosis and management of IOC in patients with SCD. In addition to iron chelation and exchange… read more here.
Keywords: revised prevalence; possible hereditary; xerocytosis derived; hereditary xerocytosis ... See more keywords
PIEZO1 activation delays erythroid differentiation of normal and hereditary xerocytosis-derived human progenitor cells
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DOI: 10.3324/haematol.2019.218503
Abstract: Hereditary xerocytosis is a dominantly inherited red cell membrane disorder caused in most cases by gain-of-function mutations in PIEZO1, encoding a mechanosensitive ion channel that translates a mechanic stimulus into calcium influx. We found that… read more here.
Keywords: piezo1 activation; progenitor cells; erythroid differentiation; piezo1 ... See more keywords