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   Articles with "herg" as a keyword



Pharmacological activation of the hERG K+ channel for the management of the long QT syndrome: A review

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recommendations! Published in 2022 at "Journal of Arrhythmia"

DOI: 10.1002/joa3.12741

Abstract: In the human heart, the rapid delayed rectifier K+ current (IKr) contributes significantly to ventricular action potential (AP) repolarization and to set the duration of the QT interval of the surface electrocardiogram (ECG). The pore‐forming… read more here.

Keywords: review; long syndrome; management; herg channel ... See more keywords

Serine mutation of a conserved threonine in the hERG K+ channel S6-pore region leads to loss-of-function through trafficking impairment

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recommendations! Published in 2020 at "Biochemical and Biophysical Research Communications"

DOI: 10.1016/j.bbrc.2020.04.003

Abstract: The human Ether-à-go-go Related Gene (hERG) encodes a potassium channel responsible for the cardiac rapid delayed rectifier K+ current, IKr, which regulates ventricular repolarization. Loss-of-function hERG mutations underpin the LQT2 form of congenital long QT… read more here.

Keywords: herg; iherg; channel; herg t634s ... See more keywords
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The Uremic Toxin P-Cresol Reduces Cell Surface Expression of Human Ether-A-Go Go-Related Gene (hERG) Channels via the Ubiquitin Ligase Nedd4-2

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recommendations! Published in 2017 at "Biophysical Journal"

DOI: 10.1016/j.bpj.2016.11.2953

Abstract: 2695-Pos Board B302 The Uremic Toxin P-Cresol Reduces Cell Surface Expression of Human Ether-A-Go Go-Related Gene (hERG) Channels via the Ubiquitin Ligase Nedd4-2 Ellen G. Avery, Shawn Lamothe, Shetuan Zhang, Jun Guo, Wentao Li, Tonghua… read more here.

Keywords: toxin cresol; cresol; herg; herg channels ... See more keywords
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The Fast Component of hERG Gating Charge: An Interaction between D411 in the S1 and S4 Residues.

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recommendations! Published in 2017 at "Biophysical journal"

DOI: 10.1016/j.bpj.2017.09.004

Abstract: Kv11.1 (hERG) is a voltage-gated potassium channel that shows very slow ionic current activation kinetics, and an unusual underlying biphasic gating charge movement with fast and slow components that differ greatly in time course. The… read more here.

Keywords: gating charge; herg; charge; activation ... See more keywords

Effects of cariprazine on hERG 1A and hERG 1A/3.1 potassium channels.

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recommendations! Published in 2019 at "European journal of pharmacology"

DOI: 10.1016/j.ejphar.2019.04.006

Abstract: Cariprazine is a novel atypical antipsychotic drug that is widely used for the treatment of schizophrenia and bipolar mania/mixed disorder. We used the whole-cell patch-clamp technique to investigate the effects of cariprazine on hERG channels… read more here.

Keywords: herg; herg herg; cariprazine herg; effects cariprazine ... See more keywords

Ondansetron and teratogenicity in rats: Evidence for a mechanism mediated via embryonic hERG blockade.

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recommendations! Published in 2018 at "Reproductive toxicology"

DOI: 10.1016/j.reprotox.2018.08.018

Abstract: The potent hERG channel blocking drug ondansetron is used off-label for treatment of nausea and vomiting in early pregnancy. Some human epidemiological studies have associated ondansetron with fetal cardiovascular defects and orofacial clefts. This study… read more here.

Keywords: mediated via; herg; ondansetron; ondansetron teratogenicity ... See more keywords

Enhancing hERG Risk Assessment with Interpretable Classificatory and Regression Models

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recommendations! Published in 2024 at "Chemical Research in Toxicology"

DOI: 10.1021/acs.chemrestox.3c00400

Abstract: The human Ether-à-go-go-Related Gene (hERG) is a transmembrane protein that regulates cardiac action potential, and its inhibition can induce a potentially deadly cardiac syndrome. In vitro tests help identify hERG blockers at early stages; however,… read more here.

Keywords: tool; regression models; pred herg; regression ... See more keywords

HergSPred: Accurate Classification of hERG Blockers/Nonblockers with Machine-Learning Models

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recommendations! Published in 2022 at "Journal of chemical information and modeling"

DOI: 10.1021/acs.jcim.2c00256

Abstract: The human ether-à-go-go-related gene (hERG) K+ channel plays an important role in cardiac action potentials. The inhibition of the hERG channel may lead to long QT syndrome (LQTS) and even sudden cardiac death. Due to… read more here.

Keywords: hergspred accurate; classification; accurate classification; classification herg ... See more keywords

Early Steps in C-Type Inactivation of the hERG Potassium Channel

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recommendations! Published in 2022 at "Journal of Chemical Information and Modeling"

DOI: 10.1021/acs.jcim.2c01028

Abstract: Fast C-type inactivation confers distinctive functional properties to the hERG potassium channel, and its association to inherited and acquired cardiac arrythmias makes the study of the inactivation mechanism of hERG at the atomic detail of… read more here.

Keywords: potassium; type inactivation; selectivity filter; inactivation ... See more keywords

Deep Learning-Based Prediction of Drug-Induced Cardiotoxicity

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recommendations! Published in 2019 at "Journal of chemical information and modeling"

DOI: 10.1021/acs.jcim.8b00769

Abstract: Blockade of the human ether-à-go-go-related gene (hERG) channel by small molecules induces the prolongation of the QT interval which leads to fatal cardiotoxicity and accounts for the withdrawal or severe restrictions on the use of… read more here.

Keywords: herg; deep learning; drug; cardiotoxicity ... See more keywords

A hERG mutation E1039X produced a synergistic lesion on IKs together with KCNQ1-R174C mutation in a LQTS family with three compound mutations

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recommendations! Published in 2018 at "Scientific Reports"

DOI: 10.1038/s41598-018-21442-6

Abstract: Congenital long QT syndrome (LQTS) caused by compound mutations is usually associated with more severe clinical phenotypes. We identified a LQTS family harboring three compound mutations in different genes (KCNQ1-R174C, hERG-E1039X and SCN5A-E428K). KCNQ1-R174C, hERG-E1039X… read more here.

Keywords: herg; herg e1039x; mutation; kcnq1 r174c ... See more keywords