The Uremic Toxin P-Cresol Reduces Cell Surface Expression of Human Ether-A-Go Go-Related Gene (hERG) Channels via the Ubiquitin Ligase Nedd4-2
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DOI: 10.1016/j.bpj.2016.11.2953
Abstract: 2695-Pos Board B302 The Uremic Toxin P-Cresol Reduces Cell Surface Expression of Human Ether-A-Go Go-Related Gene (hERG) Channels via the Ubiquitin Ligase Nedd4-2 Ellen G. Avery, Shawn Lamothe, Shetuan Zhang, Jun Guo, Wentao Li, Tonghua… read more here.
Keywords: toxin cresol; cresol; herg; herg channels ... See more keywords
Removal of hERG potassium channel affinity through introduction of an oxygen atom: Molecular insights from structure‐activity relationships of strychnine and its analogs
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DOI: 10.1016/j.taap.2018.09.042
Abstract: &NA; Nux vomica has been effectively used in Traditional Chinese Medicine. The processing of Nux vomica is necessary to reduce toxicity before it can be used in clinical practice. However, the mechanism for processing detoxification… read more here.
Keywords: channel; strychnine brucine; brucine; herg channels ... See more keywords
Pharmacological corrections of the mutant hERG channels by posaconazole
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DOI: 10.1111/1440-1681.13475
Abstract: Properties of mutant human ether‐à‐go‐go‐related gene (hERG) channels can be modified by some antibiotics. However, the pharmacological effects of posaconazole on cardiomyocyte hERG channels remain unclear. Whole‐cell patch clamping, western blotting and laser confocal scanning… read more here.
Keywords: a561 herg; herg; l539 herg; herg channels ... See more keywords
An in Vitro Assay of hERG K+ Channel Potency for a New EGFR Inhibitor FHND004
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DOI: 10.3389/fphar.2018.00577
Abstract: FHND004 is a newly synthesized epidermal growth factor receptor (EGFR) inhibitor for the treatment of non-small cell lung cancer (NSCLC). The aim of the present study was to investigate the impacts of FHND004 on human… read more here.
Keywords: egfr inhibitor; potency; herg; fhnd004 ... See more keywords