Effects of norquetiapine, the active metabolite of quetiapine, on cloned hERG potassium channels
Sign Up to like & getrecommendations! Published in 2018 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2017.11.029
Abstract: Quetiapine is an atypical antipsychotic drug that is widely used for the treatment of schizophrenia. It is mainly metabolized by a cytochrome P450 system in the liver. Norquetiapine is a major active metabolite in humans… read more here.
Keywords: herg current; active metabolite; effects norquetiapine; block ... See more keywords
Vicious LQT induced by a combination of factors different from hERG inhibition
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.930831
Abstract: Clinically, drug-induced torsades de pointes (TdP) are rare events, whereas the reduction of the human ether-à-go-go-related gene (hERG) current is common. In this study, we aimed to explore the specific factors that contribute to the… read more here.
Keywords: inhibition; action potential; combination; herg current ... See more keywords