Determination of five positive control drugs in hERG external solution (buffer) by LC-MS/MS to support in vitro hERG assay as recommended by ICH S7B.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of pharmacological and toxicological methods"
DOI: 10.2139/ssrn.4119523
Abstract: ICH S7B recommends screening for hERG channel block using patch clamp recordings to assess a drug's proarrhythmic risk. Block of the hERG channel has been associated with clinical QTC prolongation as well as the rare,… read more here.
Keywords: herg external; ich s7b; external solution;