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   Articles with "herg1" as a keyword



hERG1 and HIF-2α Behave as Biomarkers of Positive Response to Bevacizumab in Metastatic Colorectal Cancer Patients☆

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recommendations! Published in 2020 at "Translational Oncology"

DOI: 10.1016/j.tranon.2020.01.001

Abstract: Background: In search of novel biomarkers of response to bevacizumab in metastatic colorectal cancer (mCRC), we analyzed the expression and prognostic role of several proteins related to angiogenesis. Methods: A retrospective, multicenter study on 80… read more here.

Keywords: hif; bevacizumab; response bevacizumab; bevacizumab metastatic ... See more keywords

A PAS-targeting hERG1 activator reduces arrhythmic events in Jervell and Lange-Nielsen syndrome patient-derived hiPSC-CMs

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recommendations! Published in 2025 at "JCI Insight"

DOI: 10.1172/jci.insight.183444

Abstract: The hERG1 potassium channel conducts the cardiac repolarizing current, IKr. hERG1 has emerged as a therapeutic target for cardiac diseases marked by prolonged action potential duration (APD). Unfortunately, many hERG1 activators display off-target and proarrhythmic… read more here.

Keywords: jervell lange; pas; herg1; lange nielsen ... See more keywords

hERG1 channel expression associates with molecular subtypes and prognosis in breast cancer

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recommendations! Published in 2018 at "Cancer Cell International"

DOI: 10.1186/s12935-018-0592-1

Abstract: BackgroundBreast cancer (BC) is the most frequent malignancy among females worldwide. Despite several efforts and improvements in early diagnosis and treatment, there are still tumors characterized by an aggressive behavior due to unfavorable biology, thus… read more here.

Keywords: expression associates; herg1 expression; expression; herg1 ... See more keywords

Prognostic role of hERG1 Potassium Channels in Neuroendocrine Tumours of the Ileum and Pancreas

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recommendations! Published in 2022 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms231810623

Abstract: hERG1 potassium channels are widely expressed in human cancers of different origins, where they affect several key aspects of cellular behaviour. The present study was designed to evaluate the expression and clinical relevance of hERG1… read more here.

Keywords: herg1 potassium; herg1; ileum pancreas; potassium channels ... See more keywords