The Genetic Architecture of Major Depressive Disorder in Han Chinese Women
Sign Up to like & getrecommendations! Published in 2017 at "JAMA Psychiatry"
DOI: 10.1001/jamapsychiatry.2016.3578
Abstract: Importance Despite the moderate, well-demonstrated heritability of major depressive disorder (MDD), there has been limited success in identifying replicable genetic risk loci, suggesting a complex genetic architecture. Research is needed to quantify the relative contribution… read more here.
Keywords: risk; etiology; mdd; genetic architecture ... See more keywords
Heritability of fetal hemoglobin, white cell count, and other clinical traits from a sickle cell disease family cohort
Sign Up to like & getrecommendations! Published in 2019 at "American Journal of Hematology"
DOI: 10.1002/ajh.25421
Abstract: Sickle cell disease (SCD) is the most common monogenic disorder in the world. Notably, there is extensive clinical heterogeneity in SCD that cannot be fully accounted for by known factors, and in particular, the extent… read more here.
Keywords: family; cohort; cell disease; heritability ... See more keywords
Heritability and genetic integration of tooth size in the South Carolina Gullah.
Sign Up to like & getrecommendations! Published in 2017 at "American journal of physical anthropology"
DOI: 10.1002/ajpa.23290
Abstract: OBJECTIVES This article provides estimates of narrow-sense heritability and genetic pleiotropy for mesiodistal tooth dimensions for a sample of 20th century African American individuals. Results inform biological distance analysis and offer insights into patterns of… read more here.
Keywords: narrow sense; genetic integration; integration; sense heritability ... See more keywords
The Familial Risk of Autism Spectrum Disorder with and without Intellectual Disability
Sign Up to like & getrecommendations! Published in 2020 at "Autism Research"
DOI: 10.1002/aur.2417
Abstract: Autism spectrum disorder (ASD) is highly heritable, yet how its familial risk and heritability may vary by cognitive ability is not well understood. In this population‐based cohort study, we examined the familial risk and heritability… read more here.
Keywords: risk; asd asd; familial risk; asd ... See more keywords
Heritability of social behavioral phenotypes and preliminary associations with autism spectrum disorder risk genes in rhesus macaques: A whole exome sequencing study
Sign Up to like & getrecommendations! Published in 2022 at "Autism Research"
DOI: 10.1002/aur.2675
Abstract: Nonhuman primates and especially rhesus macaques (Macaca mulatta) have been indispensable animal models for studies of various aspects of neurobiology, developmental psychology, and other aspects of neuroscience. While remarkable progress has been made in our… read more here.
Keywords: heritability; autism; social behavior; rhesus macaques ... See more keywords
SNP‐based heritability and selection analyses: Improved models and new results
Sign Up to like & getrecommendations! Published in 2022 at "BioEssays"
DOI: 10.1002/bies.202100170
Abstract: Complex‐trait genetics has advanced dramatically through methods to estimate the heritability tagged by SNPs, both genome‐wide and in genomic regions of interest such as those defined by functional annotations. The models underlying many of these… read more here.
Keywords: based heritability; heritability; heritability selection; snp based ... See more keywords
Heritability of dispersal‐related larval traits in the clown anemonefish Amphiprion percula
Sign Up to like & getrecommendations! Published in 2022 at "Ecology and Evolution"
DOI: 10.1002/ece3.9541
Abstract: Abstract A major goal of marine ecology is to identify the drivers of variation in larval dispersal. Larval traits are emerging as an important potential source of variation in dispersal outcomes, but little is known… read more here.
Keywords: dispersal; ecology; heritability; larval traits ... See more keywords
Summary statistic analyses can mistake confounding bias for heritability
Sign Up to like & getrecommendations! Published in 2019 at "Genetic Epidemiology"
DOI: 10.1002/gepi.22259
Abstract: Linkage disequilibrium SCore regression (LDSC) has become a popular approach to estimate confounding bias, heritability, and genetic correlation using only genome‐wide association study (GWAS) test statistics. SumHer is a newly introduced alternative with similar aims.… read more here.
Keywords: summary statistic; confounding bias; bias heritability; statistic analyses ... See more keywords
Nasopharyngeal Epstein‐Barr virus DNA loads in high‐risk nasopharyngeal carcinoma families: Familial aggregation and host heritability
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Medical Virology"
DOI: 10.1002/jmv.26198
Abstract: Nasopharyngeal carcinoma (NPC), the most common head and neck cancer, is characterized by distinct geographic distribution and familial aggregation. Multiple risk factors, including host genetics, environmental factor, and EBV infection, have been linked to the… read more here.
Keywords: risk; genetics; ebv loads; host ... See more keywords
Suicide: Genetics and Heritability.
Sign Up to like & getrecommendations! Published in 2020 at "Current topics in behavioral neurosciences"
DOI: 10.1007/7854_2020_161
Abstract: In a topic as broad as suicide, and with as little answers as we've been able to gather so far, speaking about biological factors implies defining them and explaining why we consider them so. In… read more here.
Keywords: heritability; genetics; genetics heritability; suicide genetics ... See more keywords
Estimating Heritability from Twin Studies.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7274-6_9
Abstract: This chapter describes how the heritability of a trait can be estimated using data collected from pairs of twins. The principles of the classical twin design are described, followed by the assumptions, and some possible… read more here.
Keywords: heritability twin; chapter; heritability; twin studies ... See more keywords