A novel AMPK activator hernandezine inhibits LPS-induced TNFα production.
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DOI: 10.18632/oncotarget.18365
Abstract: Here, we found that hernandezine, a novel AMPK activator, inhibited LPS-induced TNFα expression/production in human macrophage cells (THP-1 and U937 lines). Activation of AMPK is required for hernandezine-induced anti-LPS response. AMPKα shRNA or dominant negative… read more here.
Keywords: lps induced; production; induced tnf; ampk ... See more keywords