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   Articles with "heroin" as a keyword



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Risk of Heroin Dependence in Newly Incident Heroin Users

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recommendations! Published in 2018 at "JAMA Psychiatry"

DOI: 10.1001/jamapsychiatry.2018.1214

Abstract: This study assesses data from the 2002 to 2016 US National Survey on Drug Use and Health data sets to determine the percentage of newly incident heroin users who became heroin dependent. read more here.

Keywords: newly incident; risk heroin; heroin users; heroin ... See more keywords
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Dysregulated expression of the alternatively spliced variant mRNAs of the mu opioid receptor gene, OPRM1, in the medial prefrontal cortex of male human heroin abusers and heroin self-administering male rats.

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recommendations! Published in 2020 at "Journal of neuroscience research"

DOI: 10.1002/jnr.24640

Abstract: Heroin, a mu agonist, acts through the mu opioid receptor. The mu opioid receptor gene, OPRM1, undergoes extensive alternative splicing, creating an array of splice variants that are conserved from rodent to humans. Increasing evidence… read more here.

Keywords: opioid receptor; heroin abusers; heroin; oprm1 splice ... See more keywords
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Reduction in N2 amplitude in response to deviant drug-related stimuli during a two-choice oddball task in long-term heroin abstainers

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recommendations! Published in 2017 at "Psychopharmacology"

DOI: 10.1007/s00213-017-4707-5

Abstract: RationaleChronic heroin use can cause deficits in response inhibition, leading to a loss of control over drug use, particularly in the context of drug-related cues. Unfortunately, heightened incentive salience and motivational bias in response to… read more here.

Keywords: term; response; heroin abstainers; heroin ... See more keywords
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Heroin versus cocaine: opposite choice as a function of context but not of drug history in the rat

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recommendations! Published in 2018 at "Psychopharmacology"

DOI: 10.1007/s00213-018-5115-1

Abstract: RationalePrevious studies have shown that rats trained to self-administer heroin and cocaine exhibit opposite preferences, as a function of setting, when tested in a choice paradigm. Rats tested at home prefer heroin to cocaine, whereas… read more here.

Keywords: home; heroin; drug; drug history ... See more keywords
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Total hypothalamic volume is reduced in postmortem brains of male heroin addicts

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recommendations! Published in 2017 at "European Archives of Psychiatry and Clinical Neuroscience"

DOI: 10.1007/s00406-017-0809-7

Abstract: The hypothalamus is at the core of the stress responses systems of the brain. Most interestingly, even though changes of HPA-function have been observed in opiate addiction not much is known about structural changes of… read more here.

Keywords: heroin group; volume; heroin; total hypothalamic ... See more keywords
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Kleinian Conceptualization of Heroin Addiction, Part 1: The Paranoid-Schizoid Position

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recommendations! Published in 2018 at "Clinical Social Work Journal"

DOI: 10.1007/s10615-016-0609-y

Abstract: Drug abusers are considered by many psychotherapists not to be an appropriate population for psychoanalytic treatment. Perhaps such a premise prevails due to the absence of a psychoanalytic theory that would enable analysts to understand… read more here.

Keywords: addiction; heroin addiction; schizoid position; heroin ... See more keywords
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Predictors of heroin abstinence in opiate substitution therapy in heroin-only users and dual users of heroin and crack.

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recommendations! Published in 2018 at "Addictive behaviors"

DOI: 10.1016/j.addbeh.2017.10.013

Abstract: AIMS To analyse predictors of heroin abstinence in opiate substitution therapy (OST) based on frequency of crack use and its interactions with other predictors in a clinical non-experimental setting. DESIGN Retrospective study. SETTING A community… read more here.

Keywords: use; heroin; model; heroin abstinence ... See more keywords
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Increased use of heroin as an initiating opioid of abuse: Further considerations and policy implications.

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recommendations! Published in 2018 at "Addictive behaviors"

DOI: 10.1016/j.addbeh.2018.05.030

Abstract: INTRODUCTION Previously, we reported a marked increase in the use of heroin as an initiating opioid in non-tolerant, first time opioid users. In the current paper, we sought to update and expand upon these results,… read more here.

Keywords: use; treatment; heroin; heroin initiating ... See more keywords
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Interleukin-1 signaling in the basolateral amygdala is necessary for heroin-conditioned immunosuppression

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recommendations! Published in 2017 at "Brain, Behavior, and Immunity"

DOI: 10.1016/j.bbi.2017.01.017

Abstract: Heroin administration suppresses the production of inducible nitric oxide (NO), as indicated by changes in splenic inducible nitric oxide synthase (iNOS) and plasma nitrate/nitrite. Since NO is a measure of host defense against infection and… read more here.

Keywords: production; conditioned immunosuppression; heroin; basolateral amygdala ... See more keywords
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Striatal H3K27 Acetylation Linked to Glutamatergic Gene Dysregulation in Human Heroin Abusers Holds Promise as Therapeutic Target

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recommendations! Published in 2017 at "Biological Psychiatry"

DOI: 10.1016/j.biopsych.2016.09.015

Abstract: BACKGROUND Opiate abuse and overdose reached epidemic levels in the United States. However, despite significant advances in animal and in vitro models, little knowledge has been directly accrued regarding the neurobiology of the opiate-addicted human… read more here.

Keywords: h3k27 acetylation; heroin; glutamatergic gene; heroin self ... See more keywords
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Effects of medial prefrontal cortex 5-HT7 receptor knockdown on cognitive control after acute heroin administration

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recommendations! Published in 2018 at "Brain Research"

DOI: 10.1016/j.brainres.2017.11.002

Abstract: Heroin abuse is linked to a deleterious effect on cognitive functioning in the individual. Recent evidences suggest that the serotonin7 receptor (5-HT7R) is engaged in the regulation of cognitive control and the drug use-associated behaviors.… read more here.

Keywords: heroin administration; acute heroin; heroin; cognitive control ... See more keywords