Dysregulated expression of the alternatively spliced variant mRNAs of the mu opioid receptor gene, OPRM1, in the medial prefrontal cortex of male human heroin abusers and heroin self-administering male rats.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of neuroscience research"
DOI: 10.1002/jnr.24640
Abstract: Heroin, a mu agonist, acts through the mu opioid receptor. The mu opioid receptor gene, OPRM1, undergoes extensive alternative splicing, creating an array of splice variants that are conserved from rodent to humans. Increasing evidence… read more here.
Keywords: opioid receptor; heroin abusers; heroin; oprm1 splice ... See more keywords
Do not pay attention on obvious leg compartment syndrome only. Think deeper in case of heroin abusers
Sign Up to like & getrecommendations! Published in 2018 at "ANZ Journal of Surgery"
DOI: 10.1111/ans.14464
Abstract: We report the rare simultaneous presence of compartment syndrome of abdomen, tibia and gluteal region, in a 24-year-old heroin abuser after an injection performed direct into his right tibia muscles and sitting in a chair,… read more here.
Keywords: compartment syndrome; obvious leg; heroin abusers; compartment ... See more keywords