Long-term impact of acute restraint stress on heroin self-administration, reinstatement, and stress reactivity
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DOI: 10.1007/s00213-020-05486-z
Abstract: Rationale There is a robust relationship between anxiety disorders, including post-traumatic stress disorder (PTSD) and substance abuse. In fact, 30–50% of people seeking treatment for substance abuse have a comorbid diagnosis for PTSD. Heroin use… read more here.
Keywords: acute restraint; stress; restraint stress; heroin self ... See more keywords
Striatal H3K27 Acetylation Linked to Glutamatergic Gene Dysregulation in Human Heroin Abusers Holds Promise as Therapeutic Target
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DOI: 10.1016/j.biopsych.2016.09.015
Abstract: BACKGROUND Opiate abuse and overdose reached epidemic levels in the United States. However, despite significant advances in animal and in vitro models, little knowledge has been directly accrued regarding the neurobiology of the opiate-addicted human… read more here.
Keywords: h3k27 acetylation; heroin; glutamatergic gene; heroin self ... See more keywords
Dissociative role for dorsal hippocampus in mediating heroin self‐administration and relapse through CDK5 and RhoB signaling revealed by proteomic analysis
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DOI: 10.1111/adb.12435
Abstract: Addiction is characterized by drug craving, compulsive drug taking and relapse, which is attributed to aberrant neuroadaptation in brain regions implicated in drug addiction, induced by changes in gene and protein expression in these regions… read more here.
Keywords: rhob signaling; heroin; relapse; drug ... See more keywords
Metabolomics analysis of serum in a rat heroin self-administration model undergoing reinforcement based on 1H-nuclear magnetic resonance spectra
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DOI: 10.1186/s12868-018-0404-5
Abstract: BackgroundUnderstanding the process of relapse to abused drugs and ultimately developing treatments that can reduce the incidence of relapse remains the primary goal for the study of substance dependence. Therefore, exploring the metabolite characteristics during… read more here.
Keywords: nuclear magnetic; analysis; magnetic resonance; model ... See more keywords
Altered Accumbal Dopamine Terminal Dynamics Following Chronic Heroin Self-Administration
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DOI: 10.3390/ijms23158106
Abstract: Administration of heroin results in the engagement of multiple brain regions and the rewarding and addictive effects are mediated, at least partially, through activation of the mesolimbic dopamine system. However, less is known about dopamine… read more here.
Keywords: following chronic; self administration; administration; heroin ... See more keywords