A New Insight on Activation of Human Endogenous Retroviruses (HERVs) in Malignant Melanoma upon Exposure to CuSO4
Sign Up to like & getrecommendations! Published in 2018 at "Biological Trace Element Research"
DOI: 10.1007/s12011-018-1605-6
Abstract: Human endogenous retroviruses (HERVs) are semi-conserved subtypes of long-terminal repeats containing retrotransposons that constitute approximately 8% of the genome. Under pathological conditions, the expression of HERVs is also affected by epigenetic modifications. The extent to… read more here.
Keywords: melanoma; herv; exposure; copper ... See more keywords
Antibody response against HERV-W in patients with MOG-IgG associated disorders, multiple sclerosis and NMOSD
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Neuroimmunology"
DOI: 10.1016/j.jneuroim.2019.577110
Abstract: Increased expression of the retroviruses of HERV-W family has been linked to multiple sclerosis (MS) pathophysiology; nothing is known at the moment about MOG-IgG associated disorders. We compared antibody response against HERV-W peptides among patients… read more here.
Keywords: herv; mog igg; igg associated; multiple sclerosis ... See more keywords
Human endogenous retrovirus-K (HERV-K) reverse transcriptase (RT) structure and biochemistry reveals remarkable similarities to HIV-1 RT and opportunities for HERV-K–specific inhibition
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2200260119
Abstract: Significance A large percentage of the human genome is composed of repetitive elements that are relics of past viral infections. Expression of these human endogenous retroviruses (HERVs) is associated with a variety of diseases, including… read more here.
Keywords: inhibition; structure; reverse transcriptase; herv ... See more keywords
EPCO-13. HUMAN ENDOGENOUS RETROVIRUS (HERV) PLAYS A CRITICAL ROLE IN ONCOGENIC MECHANISM INIDH1-WILD TYPE GLIOBLASTOMAS
Sign Up to like & getrecommendations! Published in 2024 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noae165.0013
Abstract: IDH1-wildtype (WT) GBMs are the most common and aggressive tumors of the central nervous system (CNS), with a median survival rate of 12-15 months, and are resistant to clinical therapies due to their heterogenous molecular… read more here.
Keywords: human endogenous; oncogenic mechanism; epco human; role ... See more keywords
Human Endogenous Retrovirus (HERV) Transcriptome Is Dynamically Modulated during SARS-CoV-2 Infection and Allows Discrimination of COVID-19 Clinical Stages
Sign Up to like & getrecommendations! Published in 2023 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.02516-22
Abstract: We report here the first high-throughput analysis of HERV loci expression along SARS-CoV-2 infection, as performed with peripheral blood mononuclear cells (PBMCs). Such cells are not directly infected by the virus but have a crucial… read more here.
Keywords: infection; herv; expression; covid ... See more keywords
Expression of Human Endogenous Retrovirus Group K (HERV-K) HML-2 Correlates with Immune Activation of Macrophages and Type I Interferon Response
Sign Up to like & getrecommendations! Published in 2023 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.04438-22
Abstract: The human endogenous retrovirus group K subgroup, HML-2, is known to be elevated in a long list of inflammation-associated diseases. However, a clear mechanism for HML-2 upregulation in response to inflammation has not been defined.… read more here.
Keywords: human endogenous; herv; expression; response ... See more keywords
Abstract 5519: psiTPTE22-HERV functions as a tumor suppressor in gastric cancer and is associated with disease outcome
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Research"
DOI: 10.1158/1538-7445.am2017-5519
Abstract: Background and aim: The novel gene psiTPTE22-HERV identified by us previously is a human endogenous retrovirus (HERV)-related gene located adjacent to the gene psiTPTE22. With a high GC content around the promoter region, expression of… read more here.
Keywords: herv; cell; psitpte22 herv; gastric cancer ... See more keywords
Abstract 6662: Studying immune responses against human endogenous retroviruses in immune checkpoint blockade-treated lung adenocarcinoma
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-6662
Abstract: Background: Clinical response to immune checkpoint blockade (ICB) is predicated upon the existence of tumor-reactive T cells, but their precise targets remain poorly defined. Some patients with low tumor mutational burden (TMB) lung adenocarcinoma (LUAD)… read more here.
Keywords: icb; lung adenocarcinoma; immune checkpoint; human endogenous ... See more keywords
Abstract P1-09-18: Activation of HERV-R is a biomarker of poor prognosis among rural Nigerian women with triple-negative breast cancer
Sign Up to like & getrecommendations! Published in 2025 at "Clinical Cancer Research"
DOI: 10.1158/1557-3265.sabcs24-p1-09-18
Abstract: Human endogenous retroviruses (HERVs) comprise genetic material from germ cells that were infected with ancient retroviruses during Pan troglodytes' evolutionary divergence. These "non-coding" repetitive elements now make up approximately 8% of the human genome. Once… read more here.
Keywords: cancer; breast cancer; herv; triple negative ... See more keywords
An ancestral retroviral protein identified as a therapeutic target in type-1 diabetes.
Sign Up to like & getrecommendations! Published in 2017 at "JCI insight"
DOI: 10.1172/jci.insight.94387
Abstract: Human endogenous retroviruses (HERVs), remnants of ancestral viral genomic insertions, are known to represent 8% of the human genome and are associated with several pathologies. In particular, the envelope protein of HERV-W family (HERV-W-Env) has… read more here.
Keywords: herv; type diabetes; protein; herv env ... See more keywords
HERV-K np9 and HERV-R env: Two endogenous retrovirus products with potential Pathogenic roles in pediatric acute lymphoblastic leukemia
Sign Up to like & getrecommendations! Published in 2024 at "International Journal of Immunopathology and Pharmacology"
DOI: 10.1177/03946320241274255
Abstract: Objectives Human endogenous retroviruses (HERVs) are integral components of the human genome, and their reactivation has been implicated in the pathogenesis of some malignancies. External viral co-infections are suspected to play a role in HERV… read more here.
Keywords: np9 herv; herv env; herv np9; herv ... See more keywords