An ancestral retroviral protein identified as a therapeutic target in type-1 diabetes.
Sign Up to like & getrecommendations! Published in 2017 at "JCI insight"
DOI: 10.1172/jci.insight.94387
Abstract: Human endogenous retroviruses (HERVs), remnants of ancestral viral genomic insertions, are known to represent 8% of the human genome and are associated with several pathologies. In particular, the envelope protein of HERV-W family (HERV-W-Env) has… read more here.
Keywords: herv; type diabetes; protein; herv env ... See more keywords
Association of Human Endogenous Retrovirus-W (HERV-W) Copies with Pemphigus Vulgaris.
Sign Up to like & getrecommendations! Published in 2023 at "Current molecular medicine"
DOI: 10.2174/1566524023666230418114152
Abstract: BACKGROUND Pemphigus is classified as a group of chronic, recurrent, and potentially fatal bullous autoimmune diseases that leads to blisters and skin lesions resulting from IgG antibodies and the loss of cellular connections in the… read more here.
Keywords: herv env; human endogenous; endogenous retrovirus; herv ... See more keywords
HERV-W-Env Involvement in Human T1D Pathogenesis—New Insights from Two Mouse Models
Sign Up to like & getrecommendations! Published in 2018 at "Diabetes"
DOI: 10.2337/db18-160-lb
Abstract: Human endogenous retroviruses (HERVs), known to represent 8% of the human genome, have been associated with several autoimmune diseases. In particular, the envelope protein of HERV-W family (HERV-W-Env), which has been involved in the pathogenesis… read more here.
Keywords: mouse models; herv env; human t1d; self geneuro ... See more keywords
Human Endogenous Retrovirus (HERV)-K env Gene Knockout Affects Tumorigenic Characteristics of nupr1 Gene in DLD-1 Colorectal Cancer Cells
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22083941
Abstract: Human endogenous retroviruses (HERVs) are suggested to be involved in the development of certain diseases, especially cancers. To elucidate the function of HERV-K Env protein in cancers, an HERV-K env gene knockout (KO) in DLD-1… read more here.
Keywords: herv; env gene; env cells; herv env ... See more keywords
HERV-K and HERV-H Env Proteins Induce a Humoral Response in Prostate Cancer Patients
Sign Up to like & getrecommendations! Published in 2022 at "Pathogens"
DOI: 10.3390/pathogens11010095
Abstract: A higher expression of human endogenous retroviruses (HERVs) has been associated with several malignancies, including prostate cancer, implying a possible use as a diagnostic or prognostic cancer biomarker. For this reason, we examined the humoral… read more here.
Keywords: prostate cancer; herv herv; herv env; herv ... See more keywords
HERV-W Envelope Triggers Abnormal Dopaminergic Neuron Process through DRD2/PP2A/AKT1/GSK3 for Schizophrenia Risk
Sign Up to like & getrecommendations! Published in 2022 at "Viruses"
DOI: 10.3390/v14010145
Abstract: An increasing number of studies have begun considering human endogenous retroviruses (HERVs) as potential pathogenic phenomena. Our previous research suggests that HERV-W Envelope (HERV-W ENV), a HERV-W family envelope protein, is elevated in schizophrenia patients… read more here.
Keywords: drd2; herv env; herv; envelope ... See more keywords