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   Articles with "herv env" as a keyword



CNSC-56. HUMAN ENDOGENOUS RETROVIRUS K ENV ACTIVATES CD98HC/EGFR SIGNALING TO PROMOTE GLIOBLASTOMA PROGRESSION

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recommendations! Published in 2025 at "Neuro-Oncology"

DOI: 10.1093/neuonc/noaf201.0264

Abstract: Human endogenous retrovirus-K (HERV-K), particularly the HML-2 subtype, is the most recently integrated human provirus and remains transcriptionally active in several cancers, including glioblastoma (GBM). Although its function in GBM has been poorly defined, we… read more here.

Keywords: egfr; human endogenous; herv env; gbm ... See more keywords
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An ancestral retroviral protein identified as a therapeutic target in type-1 diabetes.

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recommendations! Published in 2017 at "JCI insight"

DOI: 10.1172/jci.insight.94387

Abstract: Human endogenous retroviruses (HERVs), remnants of ancestral viral genomic insertions, are known to represent 8% of the human genome and are associated with several pathologies. In particular, the envelope protein of HERV-W family (HERV-W-Env) has… read more here.

Keywords: herv; type diabetes; protein; herv env ... See more keywords

HERV-K np9 and HERV-R env: Two endogenous retrovirus products with potential Pathogenic roles in pediatric acute lymphoblastic leukemia

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recommendations! Published in 2024 at "International Journal of Immunopathology and Pharmacology"

DOI: 10.1177/03946320241274255

Abstract: Objectives Human endogenous retroviruses (HERVs) are integral components of the human genome, and their reactivation has been implicated in the pathogenesis of some malignancies. External viral co-infections are suspected to play a role in HERV… read more here.

Keywords: np9 herv; herv env; herv np9; herv ... See more keywords

The expression of human endogenous retrovirus env-gene product as a hallmark of sidedness in operable colorectal cancer.

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recommendations! Published in 2025 at "Journal of Clinical Oncology"

DOI: 10.1200/jco.2025.43.16_suppl.e15632

Abstract: e15632 Background: Human Endogenous Retroviruses (HERV) constitute 8% of the human genome, where they are integrated, and usually not expressed. Despite their inactivation, many retroviral sequences present an intact ORF capable of producing retroviral transcripts… read more here.

Keywords: cancer; herv env; tumor; expression ... See more keywords

Association of Human Endogenous Retrovirus-W (HERV-W) Copies with Pemphigus Vulgaris.

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recommendations! Published in 2023 at "Current molecular medicine"

DOI: 10.2174/1566524023666230418114152

Abstract: BACKGROUND Pemphigus is classified as a group of chronic, recurrent, and potentially fatal bullous autoimmune diseases that leads to blisters and skin lesions resulting from IgG antibodies and the loss of cellular connections in the… read more here.

Keywords: herv env; human endogenous; endogenous retrovirus; herv ... See more keywords

HERV-W-Env Involvement in Human T1D Pathogenesis—New Insights from Two Mouse Models

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recommendations! Published in 2018 at "Diabetes"

DOI: 10.2337/db18-160-lb

Abstract: Human endogenous retroviruses (HERVs), known to represent 8% of the human genome, have been associated with several autoimmune diseases. In particular, the envelope protein of HERV-W family (HERV-W-Env), which has been involved in the pathogenesis… read more here.

Keywords: mouse models; herv env; human t1d; self geneuro ... See more keywords

Human Endogenous Retrovirus (HERV)-K env Gene Knockout Affects Tumorigenic Characteristics of nupr1 Gene in DLD-1 Colorectal Cancer Cells

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recommendations! Published in 2021 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms22083941

Abstract: Human endogenous retroviruses (HERVs) are suggested to be involved in the development of certain diseases, especially cancers. To elucidate the function of HERV-K Env protein in cancers, an HERV-K env gene knockout (KO) in DLD-1… read more here.

Keywords: herv; env gene; env cells; herv env ... See more keywords

HERV-K and HERV-H Env Proteins Induce a Humoral Response in Prostate Cancer Patients

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recommendations! Published in 2022 at "Pathogens"

DOI: 10.3390/pathogens11010095

Abstract: A higher expression of human endogenous retroviruses (HERVs) has been associated with several malignancies, including prostate cancer, implying a possible use as a diagnostic or prognostic cancer biomarker. For this reason, we examined the humoral… read more here.

Keywords: prostate cancer; herv herv; herv env; herv ... See more keywords

HERV-W Envelope Triggers Abnormal Dopaminergic Neuron Process through DRD2/PP2A/AKT1/GSK3 for Schizophrenia Risk

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recommendations! Published in 2022 at "Viruses"

DOI: 10.3390/v14010145

Abstract: An increasing number of studies have begun considering human endogenous retroviruses (HERVs) as potential pathogenic phenomena. Our previous research suggests that HERV-W Envelope (HERV-W ENV), a HERV-W family envelope protein, is elevated in schizophrenia patients… read more here.

Keywords: drd2; herv env; herv; envelope ... See more keywords

Transcriptional Upregulation of HERV-env Genes Under Simulated Microgravity

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recommendations! Published in 2025 at "Viruses"

DOI: 10.3390/v17030306

Abstract: Human endogenous retroviruses (HERVs) constitute about 8% of the human genome. The overexpression of HERVs has been detected in various inflammatory disorders like neuro-inflammation disorders and cancer. Interestingly, it has been reported that stress conditions… read more here.

Keywords: env genes; env herv; herv env; herv ... See more keywords