Human endogenous retrovirus HERV-K(HML-2) RNA causes neurodegeneration through Toll-like receptors.
Sign Up to like & getrecommendations! Published in 2020 at "JCI insight"
DOI: 10.1172/jci.insight.131093
Abstract: Although human endogenous retroviruses (HERVs) represent a substantial proportion of the human genome and some HERVs, such as HERV-K(HML-2), are reported to be involved in neurological disorders, little is known about their biological function. We… read more here.
Keywords: human endogenous; hml rna; hml; herv hml ... See more keywords
Widespread expression of the ancient HERV-K (HML-2) provirus group in normal human tissues
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DOI: 10.1371/journal.pbio.3001826
Abstract: Human endogenous retrovirus (HERV) transcripts are known to be highly expressed in cancers, yet their activity in nondiseased tissue is largely unknown. Using the GTEx RNA-seq dataset from normal tissue sampled at autopsy, we characterized… read more here.
Keywords: herv hml; hml provirus; tissue; expression ... See more keywords
Ancient Adversary – HERV-K (HML-2) in Cancer
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DOI: 10.3389/fonc.2021.658489
Abstract: Human endogenous retroviruses (HERV), ancient integrations of exogenous viruses, make up 8% of our genome. Long thought of as mere vestigial genetic elements, evidence is now accumulating to suggest a potential functional role in numerous… read more here.
Keywords: hml cancer; herv hml; herv; ancient adversary ... See more keywords
High Expression of HERV-K (HML-2) Might Stimulate Interferon in COVID-19 Patients
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DOI: 10.3390/v14050996
Abstract: Background. Interferon is a marker of host antiviral immunity, which is disordered in COVID-19 patients. ERV can affect the secretion of interferon through the cGAS-STING pathway. In this study, we explored whether IFN-I and HERV-K… read more here.
Keywords: herv hml; interferon; covid patients; expression herv ... See more keywords
The Role of HERV-K in Cancer Stemness
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DOI: 10.3390/v14092019
Abstract: Human endogenous retrovirus-K (HERV-K) is the most recently integrated retrovirus in the human genome, with implications for multiple disorders, including cancer. Although typically transcriptionally silenced in normal adult cells, dysregulation of HERV-K (HML-2) elements has… read more here.
Keywords: herv hml; herv; herv cancer; role herv ... See more keywords