Essential role of Notch/Hes1 signaling in postnatal pancreatic exocrine development
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Gastroenterology"
DOI: 10.1007/s00535-021-01779-y
Abstract: Notch/Hes1 signaling has been shown to play a role in determining the fate of pancreatic progenitor cells. However, its function in postnatal pancreatic maturation is not fully elucidated. We generated conditional Hes1 knockout and/or Notch… read more here.
Keywords: exocrine development; notch; role; hes1 ... See more keywords
HES1 protein oscillations are necessary for neural stem cells to exit from quiescence
Sign Up to like & getrecommendations! Published in 2021 at "iScience"
DOI: 10.1016/j.isci.2021.103198
Abstract: Summary Quiescence is a dynamic process of reversible cell cycle arrest. High-level persistent expression of the HES1 transcriptional repressor, which oscillates with an ultradian periodicity in proliferative neural stem cells (NSCs), is thought to mediate… read more here.
Keywords: exit quiescence; quiescence; hes1; stem cells ... See more keywords
A Notch‐independent mechanism contributes to the induction of Hes1 gene expression in response to hypoxia in P19 cells
Sign Up to like & getrecommendations! Published in 2017 at "Experimental Cell Research"
DOI: 10.1016/j.yexcr.2017.06.006
Abstract: ABSTRACT Hes1 is a Notch target gene that plays a major role during embryonic development. Previous studies have shown that HIF‐1&agr; can interact with the Notch intracellular domain and enhance Notch target gene expression. In… read more here.
Keywords: hypoxia; hes1; gene expression; hes1 gene ... See more keywords
Total synthesis of lindbladione, a Hes1 dimerization inhibitor and neural stem cell activator isolated from Lindbladia tubulina
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-78524-7
Abstract: Lindbladione (1) is a neural stem cell differentiation activator isolated from Lindbladia tubulina by our group. Hes1 dimerization inhibitory activity of lindbladione (1) was discovered using our original fluorescent Hes1 dimer microplate assay. We also… read more here.
Keywords: activator isolated; stem cell; hes1; neural stem ... See more keywords
Patchouli alcohol protects against myocardial ischaemia–reperfusion injury by regulating the Notch1/Hes1 pathway
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutical Biology"
DOI: 10.1080/13880209.2022.2064881
Abstract: Abstract Context Patchouli alcohol (PA) has protective effects on cerebral ischaemia/reperfusion (I/R) injury, but its efficacy on myocardial ischaemia-reperfusion (MI/R) has yet to be addressed. Objective To examine the therapeutic effect of PA on myocardial… read more here.
Keywords: reperfusion injury; hes1; reperfusion; myocardial ischaemia ... See more keywords
A Non-coding HES1 Variant Predisposes Children to Congenital Heart Disease in Chinese Population
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.631942
Abstract: Background: As a key component in the NOTCH signaling pathway, HES1 plays an important role in vertebrate heart development. Variants in the HES1 coding sequence are known to be associated with congenital heart disease (CHD).… read more here.
Keywords: heart; homozygous variant; non coding; chd ... See more keywords
miR-381-3p Cooperated With Hes1 to Regulate the Proliferation and Differentiation of Retinal Progenitor Cells
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.853215
Abstract: Retinal progenitor cells (RPCs) transplantation has become a promising therapy for retinal degeneration, which is a major kind of ocular diseases causing blindness. Since RPCs have limited proliferation and differentiation abilities toward retinal neurons, it… read more here.
Keywords: proliferation; hes1; mir 381; retinal progenitor ... See more keywords
Notch1/Hes1-PTEN/AKT/IL-17A feedback loop regulates Th17 cell differentiation in mouse psoriasis-like skin inflammation
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Medicine Reports"
DOI: 10.3892/mmr.2022.12739
Abstract: IL-17A, the effector cytokine of T helper (Th) 17 cells, plays a crucial role in the pathogenesis of psoriasis. The Notch1 and PI3K/AKT signaling pathways are implicated in Th17 cell differentiation and IL-17A production. The… read more here.
Keywords: pten akt; hes1; 17a feedback; hes1 pten ... See more keywords
Expression analysis elucidates the roles of Nicastrin, Notch4, and Hes1 in prognosis and endocrine-therapy resistance in ER-positive breast cancer patients
Sign Up to like & getrecommendations! Published in 2022 at "Research in Pharmaceutical Sciences"
DOI: 10.4103/1735-5362.363598
Abstract: Background and purpose: Although some proposed mechanisms responsible for tamoxifen resistance have already been present, further study is needed to determine the mechanisms underlying tamoxifen resistance more clearly. The critical role of Notch signaling has… read more here.
Keywords: hes1; breast; tamoxifen resistance; nicastrin notch4 ... See more keywords
HES1 promotes breast cancer stem cells by elevating Slug in triple-negative breast cancer
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Biological Sciences"
DOI: 10.7150/ijbs.53477
Abstract: Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer. TNBC is enriched with breast cancer stem cells (BCSCs), which are responsible for cancer initiation, cancer progression and worse prognosis. Our previous study… read more here.
Keywords: breast cancer; slug; tnbc; cancer ... See more keywords