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   Articles with "hes1" as a keyword



RIP140 regulates transcription factor HES1 oscillatory expression and mitogenic activity in colon cancer cells

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recommendations! Published in 2024 at "Molecular Oncology"

DOI: 10.1002/1878-0261.13626

Abstract: The transcription factor receptor‐interacting protein 140 (RIP140) regulates intestinal homeostasis and tumorigenesis through Wnt signaling. In this study, we investigated its effect on the Notch/HES1 signaling pathway. In colorectal cancer (CRC) cell lines, RIP140 positively… read more here.

Keywords: cancer; transcription factor; hes1 gene; rip140 regulates ... See more keywords
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Essential role of Notch/Hes1 signaling in postnatal pancreatic exocrine development

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recommendations! Published in 2021 at "Journal of Gastroenterology"

DOI: 10.1007/s00535-021-01779-y

Abstract: Notch/Hes1 signaling has been shown to play a role in determining the fate of pancreatic progenitor cells. However, its function in postnatal pancreatic maturation is not fully elucidated. We generated conditional Hes1 knockout and/or Notch… read more here.

Keywords: exocrine development; notch; role; hes1 ... See more keywords
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HES1 protein oscillations are necessary for neural stem cells to exit from quiescence

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recommendations! Published in 2021 at "iScience"

DOI: 10.1016/j.isci.2021.103198

Abstract: Summary Quiescence is a dynamic process of reversible cell cycle arrest. High-level persistent expression of the HES1 transcriptional repressor, which oscillates with an ultradian periodicity in proliferative neural stem cells (NSCs), is thought to mediate… read more here.

Keywords: exit quiescence; quiescence; hes1; stem cells ... See more keywords

A Notch‐independent mechanism contributes to the induction of Hes1 gene expression in response to hypoxia in P19 cells

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recommendations! Published in 2017 at "Experimental Cell Research"

DOI: 10.1016/j.yexcr.2017.06.006

Abstract: ABSTRACT Hes1 is a Notch target gene that plays a major role during embryonic development. Previous studies have shown that HIF‐1&agr; can interact with the Notch intracellular domain and enhance Notch target gene expression. In… read more here.

Keywords: hypoxia; hes1; gene expression; hes1 gene ... See more keywords

Total synthesis of lindbladione, a Hes1 dimerization inhibitor and neural stem cell activator isolated from Lindbladia tubulina

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recommendations! Published in 2020 at "Scientific Reports"

DOI: 10.1038/s41598-020-78524-7

Abstract: Lindbladione (1) is a neural stem cell differentiation activator isolated from Lindbladia tubulina by our group. Hes1 dimerization inhibitory activity of lindbladione (1) was discovered using our original fluorescent Hes1 dimer microplate assay. We also… read more here.

Keywords: activator isolated; stem cell; hes1; neural stem ... See more keywords

Patchouli alcohol protects against myocardial ischaemia–reperfusion injury by regulating the Notch1/Hes1 pathway

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recommendations! Published in 2022 at "Pharmaceutical Biology"

DOI: 10.1080/13880209.2022.2064881

Abstract: Abstract Context Patchouli alcohol (PA) has protective effects on cerebral ischaemia/reperfusion (I/R) injury, but its efficacy on myocardial ischaemia-reperfusion (MI/R) has yet to be addressed. Objective To examine the therapeutic effect of PA on myocardial… read more here.

Keywords: reperfusion injury; hes1; reperfusion; myocardial ischaemia ... See more keywords

HES1 induces ITPR1-mediated autophagy to exert anti-metastatic effects in pituitary adenomas

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recommendations! Published in 2024 at "Translational Cancer Research"

DOI: 10.21037/tcr-23-1320

Abstract: Background Pituitary adenomas (PAs) are prevalent intracranial tumors necessitating a comprehensive exploration of their molecular intricacies. This study delved into the molecular interactions among HES1 (hairy and enhancer of split 1), ITPR1 (inositol 1,4,5-trisphosphate receptor,… read more here.

Keywords: pituitary adenomas; itpr1 overexpression; itpr1 mediated; hes1 ... See more keywords

HES1 regulates bone marrow mesenchymal stromal cell function by suppressing NFATc2-mediated inflammation.

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recommendations! Published in 2025 at "Haematologica"

DOI: 10.3324/haematol.2025.288138

Abstract: The Notch target gene, Hairy and enhancer of split-1 (HES1), encodes a basic helixloop- helix transcriptional repressor that influences cell proliferation and differentiation in embryogenesis. Our previous studies indicate that HES1 is required for hematopoiesis… read more here.

Keywords: hematopoiesis; function; mesenchymal stromal; hes1 ... See more keywords
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A Non-coding HES1 Variant Predisposes Children to Congenital Heart Disease in Chinese Population

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recommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"

DOI: 10.3389/fcell.2021.631942

Abstract: Background: As a key component in the NOTCH signaling pathway, HES1 plays an important role in vertebrate heart development. Variants in the HES1 coding sequence are known to be associated with congenital heart disease (CHD).… read more here.

Keywords: heart; homozygous variant; non coding; chd ... See more keywords

miR-381-3p Cooperated With Hes1 to Regulate the Proliferation and Differentiation of Retinal Progenitor Cells

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recommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"

DOI: 10.3389/fcell.2022.853215

Abstract: Retinal progenitor cells (RPCs) transplantation has become a promising therapy for retinal degeneration, which is a major kind of ocular diseases causing blindness. Since RPCs have limited proliferation and differentiation abilities toward retinal neurons, it… read more here.

Keywords: proliferation; hes1; mir 381; retinal progenitor ... See more keywords

Hes1 in malignant tumors: from molecular mechanism to therapeutic potential

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recommendations! Published in 2025 at "Frontiers in Immunology"

DOI: 10.3389/fimmu.2025.1585624

Abstract: The occurrence and development of malignant tumors involve abnormalities in complex molecular regulatory networks, among which the abnormal activation of the transcriptional regulator hairy and enhancer of split 1 (Hes1) has attracted significant attention in… read more here.

Keywords: tumors molecular; molecular mechanism; hes1; potential hes1 ... See more keywords