Active compounds present inRosmarinus officinalis leaves andScutellaria baicalensis root evaluated as new therapeutic agents for endometriosis.
Sign Up to like & getrecommendations! Published in 2018 at "Reproductive biomedicine online"
DOI: 10.1016/j.rbmo.2018.09.018
Abstract: RESEARCH QUESTION Can carnosic acid, (CA) rosmarinic acid (RA) and wogonin (WG) inhibit the growth of cultured human endometrial stromal cells and endometriotic-like lesions induced in a BALB/c model of endometriosis? DESIGN Primary stromal cell… read more here.
Keywords: hesc; active compounds; day day; compounds present ... See more keywords
Whole-genome analysis of human embryonic stem cells enables rational line selection based on genetic variation
Sign Up to like & getrecommendations! Published in 2022 at "Cell Stem Cell"
DOI: 10.1016/j.stem.2022.01.011
Abstract: Summary Despite their widespread use in research, there has not yet been a systematic genomic analysis of human embryonic stem cell (hESC) lines at a single-nucleotide resolution. We therefore performed whole-genome sequencing (WGS) of 143… read more here.
Keywords: human embryonic; analysis human; stem; hesc ... See more keywords
Are atrial human pluripotent stem cell-derived cardiomyocytes ready to identify drugs that beat atrial fibrillation?
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-21949-z
Abstract: A key issue in the development of atrial-selective antiarrhythmic drugs is the limited access to human heart tissue. Goldfracht et al. have used atrialand ventricular-differentiated human embryonic stem cell‐derived cardiomyocytes (hESC-CMs) to dissect chamber-selective actions… read more here.
Keywords: stem cell; hesc; derived cardiomyocytes; cell derived ... See more keywords
Effect of exposure to ionizing radiation on competitive proliferation and differentiation of hESC
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Radiation Biology"
DOI: 10.1080/09553002.2023.2146231
Abstract: Abstract Purpose We studied the effects of computed tomography (CT) scan irradiation on proliferation and differentiation of human embryonic stem cells (hESCs). It was reported that hESC is extremely radiosensitive; exposure of hESC in cultures… read more here.
Keywords: h9gfp; hesc; radiation; differentiation ... See more keywords
Fabrication of vascularized tissue constructs under chemically defined culture conditions.
Sign Up to like & getrecommendations! Published in 2020 at "Biofabrication"
DOI: 10.1088/1758-5090/aba0c2
Abstract: Three-dimensional (3D) biofabrication techniques that enable the production of multicellular tissue equivalents for applications in basic biology, drug screening and regenerative medicne. Fabrication of these tissue constructs with in-built microvasculature enables recapitulation of the biological… read more here.
Keywords: hesc; fabrication vascularized; tissue; culture ... See more keywords
Inducible apelin receptor knockdown reduces differentiation efficiency and contractility of hESC-derived cardiomyocytes
Sign Up to like & getrecommendations! Published in 2022 at "Cardiovascular Research"
DOI: 10.1093/cvr/cvac065
Abstract: Abstract Aims The apelin receptor, a G protein-coupled receptor, has emerged as a key regulator of cardiovascular development, physiology, and disease. However, there is a lack of suitable human in vitro models to investigate the… read more here.
Keywords: receptor knockdown; apelin receptor; hesc; heart ... See more keywords
Retinoid Signaling Controlled by SRC-2 in Decidualization Revealed by Transcriptomics.
Sign Up to like & getrecommendations! Published in 2018 at "Reproduction"
DOI: 10.1530/rep-18-0282
Abstract: Establishment of a successful pregnancy requires not only implantation of a healthy embryo into a receptive uterus but also progesterone receptor (PGR)-dependent transformation of endometrial stromal cells (ESCs) into specialized decidual cells. Decidual cells support… read more here.
Keywords: hesc; controlled src; retinoid signaling; signaling controlled ... See more keywords