Laminin-511-derived recombinant fragment and Rho kinase inhibitor Y-27632 facilitate serial cultivation of keratinocytes differentiated from human embryonic stem cells
Sign Up to like & getrecommendations! Published in 2021 at "Regenerative Therapy"
DOI: 10.1016/j.reth.2021.07.004
Abstract: Introduction Keratinocytes derived from pluripotent stem cells have a short proliferative lifespan under conventional culture conditions that are optimized for keratinocytes. Recently, a Rho kinase inhibitor, Y-27632, had been used as a standard supplement for… read more here.
Keywords: serial cultivation; laminin 511; derived keratinocytes; cultivation ... See more keywords
Repair of acute liver damage with immune evasive hESC derived hepato-blasts.
Sign Up to like & getrecommendations! Published in 2020 at "Stem cell research"
DOI: 10.1016/j.scr.2020.102010
Abstract: Human embryonic stem cells (hESCs) can undergo unlimited self-renewal and differentiate into hepatic cells, including expandable hepato-blasts (HBs) and hepatocyte-like cells (HLCs) in vitro. Therefore, hESC-derived HBs have the potential to become a renewable cell… read more here.
Keywords: hepato blasts; liver damage; hesc derived;
Comparison of human amniotic membrane decellularisation approaches for hESC-derived RPE cells culture
Sign Up to like & getrecommendations! Published in 2022 at "BMJ Open Ophthalmology"
DOI: 10.1136/bmjophth-2022-000981
Abstract: Objective Recent clinical studies have shown that the transplantation of functional retinal pigment epithelium (RPE) cells can prevent the onset of RPE degeneration in age-related macular degeneration. This study aimed to investigate the potential of… read more here.
Keywords: rpe cells; derived rpe; hesc derived; ham ... See more keywords
Posttransplant Characterization of Long-term Functional hESC-Derived Pancreatic Endoderm Grafts
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DOI: 10.2337/db18-0788
Abstract: The paucity of human donors limits broadened application of β-cell replacement therapy. Insulin-producing cells derived from human embryonic stem cells (hESCs) have recently been investigated clinically as a feasible surrogate to primary tissue. Herein, we… read more here.
Keywords: long term; posttransplant characterization; pancreatic endoderm; hesc derived ... See more keywords
The impact of different implantation sites and sex on the differentiation of human pancreatic endoderm cells into insulin-secreting cells in vivo.
Sign Up to like & getrecommendations! Published in 2023 at "Diabetes"
DOI: 10.2337/db22-0692
Abstract: Few studies have examined the differentiation of human embryonic stem cell (hESC)-derived pancreatic endoderm cells (PECs) in different implantation sites. Here, we investigate the influence of implantation site and recipient sex on the differentiation of… read more here.
Keywords: implantation sites; pancreatic endoderm; hesc derived; differentiation human ... See more keywords