Nanophytosomes of hesperidin and of hesperetin: Preparation, characterization, and in vivo evaluation
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology and Applied Biochemistry"
DOI: 10.1002/bab.2404
Abstract: Hesperidin and hesperetin are two important plant flavanones abundantly found in citrus fruit. They have discovered many biological activities to treat diseases, including cancer, diabetes, and Alzheimer's disease. Despite their various benefits, they have poor… read more here.
Keywords: preparation characterization; hesperidin hesperetin; hesperetin; nanophytosomes hesperidin ... See more keywords
Hesperetin suppresses RANKL‐induced osteoclastogenesis and ameliorates lipopolysaccharide‐induced bone loss
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.27924
Abstract: Destructive bone diseases caused by osteolysis are increasing in incidence. They are characterized by an excessive imbalance of osteoclast formation and activation. During osteolysis, the activation of nuclear factor‐κB (NF‐κB) and mitogen‐activated protein kinase (MAPK)… read more here.
Keywords: induced osteoclastogenesis; induced bone; rankl induced; bone ... See more keywords
Hesperetin (Citrus peel flavonoid aglycone) encapsulation using pea protein- high methoxyl pectin electrostatic complexes: Complex optimization and biological activity.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the science of food and agriculture"
DOI: 10.1002/jsfa.11874
Abstract: BACKGROUND Orange pomace polyphenols have potential for use as nutraceutical ingredients in functional foods and beverages. However, due to their low water solubility and bioaccesibility, they are not being utilized to their full potential. The… read more here.
Keywords: methoxyl pectin; pea protein; hesperetin; high methoxyl ... See more keywords
Hesperetin ameliorates lipopolysaccharide-induced acute lung injury in mice through regulating the TLR4-MyD88-NF-κB signaling pathway.
Sign Up to like & getrecommendations! Published in 2019 at "Archives of pharmacal research"
DOI: 10.1007/s12272-019-01200-6
Abstract: Hesperetin, a major bioflavonoid in sweet oranges and lemons, exerts an anti-inflammatory effect in pulmonary diseases; however, its effect on lipopolysaccharide (LPS)-induced acute lung injury is unclear. This study investigated the effect of hesperetin on… read more here.
Keywords: hesperetin; acute lung; lung injury; induced acute ... See more keywords
The protective effect of hesperetin on UVA-induced matrix metalloproteinase-1 (MMP-1) in primary human dermal fibroblasts and mouse skin through modulation of nuclear factor erythroid 2- related factor 2 (NRF2)-regulated antioxidant defenses
Sign Up to like & getrecommendations! Published in 2017 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2017.04.127
Abstract: Skin aging is an accumulation of collagen degradation caused by matrix metalloproteinase-1 (MMP-1) mainly present in human dermal fibroblasts (HDFs). Increased activity of Nrf2, the transcription factor of antioxidant genes, to counteract oxidative stress is… read more here.
Keywords: uva induced; antioxidant defenses; mouse skin; mmp ... See more keywords
Hesperetin mitigates isoproterenol induced cardiac hypertrophy by augmenting Nrf2/ARE signaling pathway
Sign Up to like & getrecommendations! Published in 2018 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2018.10.068
Abstract: Background Cardiac hypertrophy characterized by excessive oxidative stress leading to collagen deposition, predisposes the heart to failure (HF) if left unresolved. Thus, understanding the signaling mechanisms involved in excessive extracellular matrix deposition is necessary to… read more here.
Keywords: cardiac hypertrophy; nrf2 signaling; hypertrophy; hesperetin ... See more keywords
Design, synthesis and investigation of potential anti‐inflammatory activity of O‐alkyl and O‐benzyl hesperetin derivatives
Sign Up to like & getrecommendations! Published in 2018 at "International Immunopharmacology"
DOI: 10.1016/j.intimp.2018.05.009
Abstract: &NA; Hesperetin has been known to exert several activities such as anti‐oxidant, antitumor and anti‐inflammatory. To find hesperetin derivatives showing better activity, sixteen novel hesperetin derivatives were designed and synthesized. The new obtained compounds were… read more here.
Keywords: anti inflammatory; inflammatory activity; compound; hesperetin ... See more keywords
Hesperetin attenuated acetaminophen-induced hepatotoxicity by inhibiting hepatocyte necrosis and apoptosis, oxidative stress and inflammatory response via upregulation of heme oxygenase-1 expression.
Sign Up to like & getrecommendations! Published in 2020 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2020.106435
Abstract: Acetaminophen (APAP) is a common antipyretic and analgesic drug, but its overdose can induce acute liver failure with lack of effective therapies. Hesperetin, a dihydrogen flavonoid compound, has been revealed to exert multiple pharmacological activities.… read more here.
Keywords: apoptosis; inflammatory response; apap induced; hesperetin ... See more keywords
Hesperidin and its aglycone hesperetin in breast cancer therapy: A review of recent developments and future prospects
Sign Up to like & getrecommendations! Published in 2021 at "Saudi Journal of Biological Sciences"
DOI: 10.1016/j.sjbs.2021.07.046
Abstract: Breast cancer (BC) has high incidence and mortality rates, making it a major global health issue. BC treatment has been challenging due to the presence of drug resistance and the limited availability of therapeutic options… read more here.
Keywords: hesperidin aglycone; breast cancer; aglycone hesperetin; hesperetin ... See more keywords
Improved bioavailability and anticancer efficacy of Hesperetin on breast cancer via a self-assembled rebaudioside A nanomicelles system.
Sign Up to like & getrecommendations! Published in 2021 at "Toxicology and applied pharmacology"
DOI: 10.1016/j.taap.2021.115511
Abstract: Hesperetin (HSP) has excellent biological activities with poor water solubility which limits its clinical development. In this study, we successfully prepared a novel, self-assembled micelle based on Rebaudioside A (RA) for oral delivery of HSP… read more here.
Keywords: bioavailability; hsp; breast cancer; self assembled ... See more keywords
4-Methylcoumarin-[5,6-g]-hesperetin attenuates inflammatory responses in alcoholic hepatitis through PPAR-γ activation.
Sign Up to like & getrecommendations! Published in 2019 at "Toxicology"
DOI: 10.1016/j.tox.2019.04.004
Abstract: 4-Methylcoumarin-[5,6-g]-hesperetin (4-MCH) is a hesperidin derivative produced by the structural modification of hesperetin. Alcoholic hepatitis (AH) is the origin of many serious liver diseases that are accompanied by hepatic inflammation. In this study, we detected… read more here.
Keywords: ppar; alcoholic hepatitis; ppar activation; hesperetin ... See more keywords