Synthesis and characterization of hesperetin derivatives and toxicity level of the zebrafish model
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DOI: 10.1016/j.heliyon.2021.e06066
Abstract: Hesperetin derivatives were synthesized through the esterification of acid chlorides with hesperetin under ambient reaction conditions with good yields. The product was confirmed using different spectral techniques. It was treated on zebrafish embryos to study… read more here.
Keywords: hesperetin derivatives; characterization hesperetin; concentration; toxicity level ... See more keywords
Design, synthesis and investigation of potential anti‐inflammatory activity of O‐alkyl and O‐benzyl hesperetin derivatives
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DOI: 10.1016/j.intimp.2018.05.009
Abstract: &NA; Hesperetin has been known to exert several activities such as anti‐oxidant, antitumor and anti‐inflammatory. To find hesperetin derivatives showing better activity, sixteen novel hesperetin derivatives were designed and synthesized. The new obtained compounds were… read more here.
Keywords: anti inflammatory; inflammatory activity; compound; hesperetin ... See more keywords
Design, Synthesis and Investigation of the Potential Anti-Inflammatory Activity of 7-O-Amide Hesperetin Derivatives
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DOI: 10.3390/molecules24203663
Abstract: To develop new anti-inflammatory agents, a series of 7-O-amide hesperetin derivatives was designed, synthesized and evaluated for anti-inflammatory activity using RAW264.7 cells. All compounds showed inhibitory effect on LPS-induced NO production. Among them, 7-O-(2-(Propylamino)-2-oxoethyl)hesperetin (4d)… read more here.
Keywords: anti inflammatory; amide hesperetin; inflammatory activity; activity ... See more keywords
Antioxidant and Antitumor Activities of Newly Synthesized Hesperetin Derivatives
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DOI: 10.3390/molecules27030879
Abstract: Hesperetin is a class of natural products with a wide range of sources and remarkable biological activities. In this study, we described the synthesis of a series of novel hesperetin derivatives and evaluated the in… read more here.
Keywords: antioxidant antitumor; hesperetin derivatives; hesperetin; antitumor activities ... See more keywords