Effect of hesperidin on fluoride‐induced neurobehavioral and biochemical changes in rats
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.22575
Abstract: Fluoride is the second largest contaminant of drinking water. Fluoride toxicity is a major concern in the endemic areas where a high amount of fluoride is present in ground water. Oxidative stress has been proposed… read more here.
Keywords: fluoride induced; biochemical changes; effect hesperidin; hesperidin ... See more keywords
Anti-inflammatory and anti-aggregating effects of rangpur in the first trimester of growth. UPLC-ESI-MSE profile and quantification of hesperidin.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the science of food and agriculture"
DOI: 10.1002/jsfa.11764
Abstract: BACKGROUND Citrus fruits are a rich source of valuable molecules, and their industrial processing produces wastes that are scarcely transformed into pectin. These Citrus residues, including seeds and peels, also contain numerous pharmacologically important substances.… read more here.
Keywords: quantification; growth; anti inflammatory; hesperidin ... See more keywords
Demethylating and anti‐hepatocarcinogenic potential of hesperidin, a natural polyphenol of Citrus juices
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.22621
Abstract: Hepatocellular carcinoma (HCC) is a neoplasia representing the fifth most common malignancy worldwide and the third cause of death from cancer. Diets with high content in fruits and vegetables are widely recommended for their health‐promoting… read more here.
Keywords: hepatocarcinogenic potential; potential hesperidin; hesperidin; anti hepatocarcinogenic ... See more keywords
The effect of hesperidin supplementation on metabolic profiles in patients with metabolic syndrome: a randomized, double-blind, placebo-controlled clinical trial
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Nutrition"
DOI: 10.1007/s00394-019-02105-2
Abstract: Hesperidin as an antioxidant flavonoid exerts anti-adipogenic, anti-inflammatory, anti-oxidant and anti-hypercholesterolemic effects. Besides, the increasing prevalence of metabolic syndrome (MetS) and its allied complications, on the one hand, and the willingness of individuals to use… read more here.
Keywords: clinical trial; trial; hesperidin; metabolic syndrome ... See more keywords
Cerebroprotective Potential of Hesperidin Nanoparticles Against Bilateral Common Carotid Artery Occlusion Reperfusion Injury in Rats and In silico Approaches
Sign Up to like & getrecommendations! Published in 2019 at "Neurotoxicity Research"
DOI: 10.1007/s12640-019-00098-8
Abstract: Cerebral ischemia-reperfusion (C I/R) accelerates neuronal injury through the overproduction of reactive oxygen species due to mitochondrial dysfunction. Hesperidin has cerebroprotective effects due to its antioxidant and anti-apoptotic nature against oxidative damage caused by C… read more here.
Keywords: nano hesperidin; hesperidin; bilateral common; common carotid ... See more keywords
Hesperidin inhibits cell proliferation and induces mitochondrial-mediated apoptosis in human lung cancer cells through down regulation of β-catenin/c-myc
Sign Up to like & getrecommendations! Published in 2019 at "Biocatalysis and Agricultural Biotechnology"
DOI: 10.1016/j.bcab.2019.101065
Abstract: Abstract The aim of this study is to evaluate the mechanism of actions involved in the anticancer effect of hesperidin against cell proliferation and inducing apoptosis in human lung cancer A549 cells. MTT assay were performed,… read more here.
Keywords: human lung; cell proliferation; hesperidin; lung cancer ... See more keywords
Hesperidin protects against chemically induced hepatocarcinogenesis via modulation of Nrf2/ARE/HO-1, PPARγ and TGF-β1/Smad3 signaling, and amelioration of oxidative stress and inflammation.
Sign Up to like & getrecommendations! Published in 2017 at "Chemico-biological interactions"
DOI: 10.1016/j.cbi.2017.09.015
Abstract: Hesperidin is a plant-derived bioflavonoid with promising antitumor efficacy, though the underlying mechanisms of action remain poorly elucidated. Thus, we evaluated the in vivo chemopreventive effect of hesperidin against diethylnitrosamine (DEN)-induced hepatocarcinogenesis. We demonstrated the modulatory… read more here.
Keywords: smad3; smad3 signaling; hesperidin; nrf2 ppar ... See more keywords
Hesperidin reverses perivascular adipose-mediated aortic stiffness with aging
Sign Up to like & getrecommendations! Published in 2017 at "Experimental Gerontology"
DOI: 10.1016/j.exger.2017.08.003
Abstract: ABSTRACT We tested the hypothesis that hesperidin would reverse age‐related aortic stiffness, perivascular adipose (PVAT) mediated‐arterial stiffening and PVAT advanced glycation end‐products (AGE) accumulation. Aortic pulse wave velocity (aPWV) and intrinsic mechanical stiffness, two measures… read more here.
Keywords: mechanical stiffness; stiffness; age; perivascular adipose ... See more keywords
Pharmacoinformatics approach for the identification of Polo-like kinase-1 inhibitors from natural sources as anti-cancer agents.
Sign Up to like & getrecommendations! Published in 2018 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2018.05.023
Abstract: Polo-like kinase-1 (PLK-1) plays a key role in cell cycle progression during mitosis. Overexpression/dysfunction of PLK-1 is directly associated with cancerous transformation and has been reported in different cancer types. Here, we employed high throughput… read more here.
Keywords: like kinase; kinase; polo like; hesperidin ... See more keywords
A mechanistic review of the anticancer potential of hesperidin, a natural flavonoid from citrus fruits.
Sign Up to like & getrecommendations! Published in 2021 at "Nutrition research"
DOI: 10.1016/j.nutres.2021.05.011
Abstract: Hesperidin, a phytoactive compound, is an abundant and economical dietary bioflavonoid possessing numerous biological and medicinal benefits. Several studies have strongly proven the significant chemotherapeutic potential of hesperidin. Therefore, this review aims to bring together… read more here.
Keywords: mechanistic review; review anticancer; potential hesperidin; hesperidin ... See more keywords
α-Monoglucosyl Hesperidin but Not Hesperidin Induces Brown-Like Adipocyte Formation and Suppresses White Adipose Tissue Accumulation in Mice.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.8b06647
Abstract: Hesperidin (HES) is a flavanone glycoside found in citrus peel that contributes to its bitter taste. It has low water solubility and poor oral bioavailability. To improve its solubility and bioavailability, α-monoglucosyl hesperidin (αGH) has… read more here.
Keywords: brown like; white adipose; formation; hesperidin ... See more keywords