Synthesis and search for compounds with hemostatic activity in the series of 4-(het)aryl-4-oxobut-2-enoic acid derivatives
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DOI: 10.1007/s11172-017-1914-5
Abstract: New 4-aryl-2-(4-arylamino)-1-(piperazin-1-yl)but-2-ene-1,4-diones and 2-{[2-(3-R-adamantan-1-yl)-2-oxoethylidene]hydrazinyl}-4-(het)aryl-4-oxobut-2-enoic acids were synthesized and used to obtain water-soluble compounds. Their influence on the blood coagulation system was studied, which revealed compounds with a high hemostatic activity and a low acute toxicity.… read more here.
Keywords: oxobut enoic; aryl oxobut; hemostatic activity; het aryl ... See more keywords
Synthesis and some properties of the salts of N-(het)aryl-N´-hydroxydiazene N-oxides
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DOI: 10.1007/s11172-020-2759-x
Abstract: Salts of N-(het)aryl-N´-hydroxydiazene N-oxides were synthesized by the reaction of sodium nitrohydroxylaminate (Angeli´s salt) with the appropriate nitro compounds. The ion exchange reactions gave the corresponding copper and lead salts. The thermal stability of the… read more here.
Keywords: aryl hydroxydiazene; synthesis properties; hydroxydiazene oxides; het aryl ... See more keywords
Synthesis of het(aryl) imidazole C-nucleoside analogues by CoFe2O4 NPs catalyzed muti-component coupling reaction.
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DOI: 10.1016/j.carres.2019.03.013
Abstract: A general synthesis of hetaryl and aryl C-4(5) linked imidazole C-nucleoside analogues has been developed by the reaction of sugar alkynes with het(aryl) iodides, KMnO4/TBAB oxidation and CoFe2O4 NPs catalyzed muti-component coupling of the corresponding… read more here.
Keywords: catalyzed muti; imidazole nucleoside; cofe2o4 nps; het aryl ... See more keywords
Bis(het)aryl-1,2,3-triazole quinuclidines as α7 nicotinic acetylcholine receptor ligands: Synthesis, structure affinity relationships, agonism activity, [18F]-radiolabeling and PET study in rats.
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DOI: 10.1016/j.ejmech.2019.06.049
Abstract: In this paper we describe the design and synthesis of bis(Het)Aryl-1,2,3-triazole quinuclidine α7R ligands using an efficient three-step sequence including a Suzuki-Miyaura cross coupling reaction with commercially available and home-made boron derivatives. The exploration of… read more here.
Keywords: bis het; nicotinic acetylcholine; quinuclidines nicotinic; triazole quinuclidines ... See more keywords
Synthesis of novel 8-(het)aryl-6H-pyrano[4′,3′:4,5]thieno[3,2-b]pyridines by 6-endo-dig cyclization of Sonogashira products and halolactonizations with Cu salts/NXS. Preliminary antitumor evaluation
Sign Up to like & getrecommendations! Published in 2019 at "Tetrahedron"
DOI: 10.1016/j.tet.2019.01.054
Abstract: Abstract Novel 8-(het)aryl-6H-pyrano[4′,3′:4,5]thieno[3,2-b]pyridines were prepared in good to high yields by a tandem one-pot procedure of Sonogashira coupling and 6-endo-dig lactonization from 3-bromothieno[3,2-b]pyridine-2-carboxylic acid and (het)arylalkynes. Sonogashira coupling products were also prepared from the corresponding… read more here.
Keywords: endo dig; aryl pyrano; het; novel het ... See more keywords
Regioselective competitive synthesis of 3,5-bis(het) aryl pyrrole-2-carboxylates/carbonitriles vs. β-enaminones from β-thioxoketones
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DOI: 10.1016/j.tetlet.2021.153373
Abstract: Abstract An easily adaptable protocol for the synthesis of 3,5-bis(het)aryl-2-carboxylate/nitrile pyrroles and the related 2,3,5-tri(het)aryl-pyrroles with complementary regioselectivity from the corresponding 1,3-bis(het)aryl-1,3-monothio diketones or β-enaminone precursors has been reported. Initially, regioselective base catalyzed condensation of… read more here.
Keywords: synthesis bis; bis het; het; het aryl ... See more keywords
Room-Temperature Synthesis of 1,3,5-Tri(het)aryl Benzene from Nitroalkenes Using Pd(OAc)2: Complete Mechanistic and Theoretical Studies.
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DOI: 10.1021/acs.orglett.2c01662
Abstract: Herein, a room-temperature catalytic pathway for 1,3,5-tri(het)aryl derivatives from nitroalkenes using simple Pd(OAc)2 is presented. This newly developed C-C bond-forming methodology takes place in a cascade manner with the initial pallado-Morita-Baylis-Hillman (MBH) type adduct. The… read more here.
Keywords: tri het; methodology; het aryl; nitroalkenes using ... See more keywords
One-Pot Synthesis of 2-(Het)aryl/alkyl-3-cyanobenzofurans from 2-(2-Bromoaryl)-3-(het)aryl-3-(methylthio)acrylonitriles and Benzyl Carbamate
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DOI: 10.1021/acsomega.8b01172
Abstract: A one-pot synthesis of 2-(het)aryl/alkyl-3-cyanobenzofurans has been reported. The overall sequence involves base-induced reaction of 2-(2-bromoaryl)-3-(het)aryl-3-(methylthio)acrylonitriles with benzyl carbamate, generating α-(het)aroyl-α-(2-bromoaryl)acetonitriles, which are in situ subjected to copper-catalyzed intramolecular O-arylation, furnishing the 2-(het)aryl/alkyl-3-cyanobenzofurans in high… read more here.
Keywords: bromoaryl het; aryl alkyl; het aryl; aryl ... See more keywords
Rapid synthesis of 3-amino-1H-isochromene from ortho-ynamidyl het(aryl) aldehyde derivatives
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DOI: 10.1039/d0ra00768d
Abstract: A simple and original efficient synthesis of 3-amino-1H-isochromene bearing a bromine atom at the C-1 position via a 6-endo-cyclization approach from in situ generated ortho-ynamidyl het(aryl) aldehyde derivatives is achieved under mild reaction conditions and… read more here.
Keywords: ynamidyl; amino isochromene; synthesis amino; ynamidyl het ... See more keywords
Synthesis and Structure of 4-Het(aryl)-3,5,5-trimethoxycarbonyl-2-pyrrolidones
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DOI: 10.1134/s1070363219070260
Abstract: Condensation of 2-het(aryl)-1,1-dimethoxycarbonylethenes with acetylaminomalonic acid ester afforded (3R*,4S*)-4-(4-methoxyphenyl)-, (3R*,4S*)-4-(3,4-methylenedioxyphenyl)-, (3R*,4S*)-4-(4-dimethylaminophenyl)-, (3R*,4S*)-4-(2-furyl)-, (3R*,4S*)-4-(indol-3-yl)-, (3R*,4S*)-4-(1-methylindol-3-yl)-, and (3R*,4S*)-4-(1-benzylindol-3-yl)-3,5,5-tris(methoxycarbonyl)-2-pyrrolidones. read more here.
Keywords: het; aryl trimethoxycarbonyl; synthesis structure; het aryl ... See more keywords