Carboxylative Coupling of Chloromethyl(hetero)arenes with Allyltrimethoxysilane Catalyzed by Palladium Nanoparticles
Sign Up to like & getrecommendations! Published in 2017 at "Asian Journal of Organic Chemistry"
DOI: 10.1002/ajoc.201600510
Abstract: The palladium-catalyzed three-component coupling of (chloromethyl)arenes or (chloromethyl)heteroarenes, allytrimethoxysilane, and carbon dioxide (carboxylative Hiyama coupling reaction) was successfully conducted to produce α,β-unsaturated esters in satisfactory to good yields. The carboxylative Hiyama coupling reaction proceeded smoothly… read more here.
Keywords: palladium nanoparticles; carboxylative coupling; coupling chloromethyl; hetero arenes ... See more keywords
Ni-Catalyzed C-H Cyanation of (Hetero)arenes with 2-Cyanoisothiazolidine 1,1-Dioxide as a Cyanation Reagent.
Sign Up to like & getrecommendations! Published in 2021 at "Organic letters"
DOI: 10.1021/acs.orglett.1c00468
Abstract: A nickel-catalyzed C-H cyanation reaction of arenes has been developed using 2-cyanoisothiazolidine 1,1-dioxide as an electrophilic cyanation reagent. Many different directing groups can be used in this cyanation to obtain a series of cyanation products… read more here.
Keywords: cyanation reagent; hetero arenes; cyanation hetero; cyanation ... See more keywords
Selective C–H Iodination of (Hetero)arenes
Sign Up to like & getrecommendations! Published in 2021 at "Organic Letters"
DOI: 10.1021/acs.orglett.1c01530
Abstract: Iodoarenes are versatile intermediates and common synthetic targets in organic synthesis. Here, we present a strategy for selective C–H iodination of (hetero)arenes with a broad functional group tolerance. We demonstrate the utility and differentiation to… read more here.
Keywords: iodination; iodination hetero; hetero arenes; selective iodination ... See more keywords
Rhodium-Catalyzed Atroposelective C-H Arylation of (Hetero)Arenes Using Carbene Precursors as Arylating Reagents.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c00968
Abstract: Rhodium(III)-catalyzed C-H activation-based arylation of sterically hindered (hetero)arenes has been realized using diazo compounds and triazoles as arylating reagents for atroposelective synthesis of two classes of biaryls. The coupling of 3-substituted indoles and N-sulfonyltriazoles afforded… read more here.
Keywords: hetero arenes; rhodium catalyzed; arylating reagents; catalyzed atroposelective ... See more keywords
Hypervalent Iodine Reagents Enable C(sp2)-H Amidation of (Hetero)arenes with Iminophenylacetic Acids.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c02751
Abstract: Sulfonamide-containing (hetero)arenes are widely present in bioactive molecules. Here, we report the sulfonamidyl (hetero)arenes synthesis by the C(sp2)-H amidation from bench-stable amidyl-iminophenylacetic acids. The hypervalent iodine reagents covalently activated iminophenylacetic acids for the facile sulfonamidyl… read more here.
Keywords: hypervalent iodine; iodine reagents; iminophenylacetic acids; hetero arenes ... See more keywords
Direct Reductive Arylation of Imines with Electron-Deficient (Hetero) Arenes via Electrosynthesis to Access Benzylic Amines.
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DOI: 10.1021/acs.orglett.2c02900
Abstract: In this paper, a direct access to benzylic amines from imines and electron-deficient (hetero) arenes via electrochemical radical-radical cross-coupling is described. The reaction has the characteristics of the wide range of substrates, excellent functional group… read more here.
Keywords: electron deficient; imines electron; benzylic amines; deficient hetero ... See more keywords
Photoinduced Defluorinative Branch-Selective Olefination of Multifluoro (Hetero)arenes.
Sign Up to like & getrecommendations! Published in 2023 at "Organic letters"
DOI: 10.1021/acs.orglett.3c00115
Abstract: We report a photoredox platform for constructing styrenyl polyfluoro (hetero)arenes with branch selectivity by taking advantage of sulfinate as both a radical-relay precursor and a sacrificial nucleofuge. This protocol merges photoredox catalysis with radical-radical coupling… read more here.
Keywords: hetero; defluorinative branch; photoinduced defluorinative; branch selective ... See more keywords
Thianthrenation-Enabled Pyrrolidin-2-yl and Tetrahydrofuran-2-yl Methylation of (Hetero)Arenes.
Sign Up to like & getrecommendations! Published in 2023 at "Organic letters"
DOI: 10.1021/acs.orglett.3c00582
Abstract: The mild and efficient palladium-catalyzed pyrrolidin-2-yl and tetrahydrofuran-2-yl methylation of (hetero)arenes has been developed. A wide range of (hetero)arenes underwent the regioselective thianthrenation to generate the arylthianthrenium triflate, and the developed Pd-catalyzed alkene carboamination and… read more here.
Keywords: methylation hetero; tetrahydrofuran; tetrahydrofuran methylation; hetero arenes ... See more keywords
Trifluoromethylations of (Hetero)arenes and Polarized Alkenes Using Trifluoroacetic Anhydride under Photoredox Catalysis.
Sign Up to like & getrecommendations! Published in 2023 at "Organic letters"
DOI: 10.1021/acs.orglett.3c00890
Abstract: A novel trifluoromethylation of (hetero)arenes and polarized alkenes using simple trifluoroacetic anhydride (TFAA) as the low price CF3 source under photoredox catalysis was developed without using additives such as bases, hyperstoichiometric oxidant, or auxiliaries. The… read more here.
Keywords: alkenes using; photoredox catalysis; arenes polarized; trifluoroacetic anhydride ... See more keywords
Access to Substituted Propenoic Acids via Rh(III)-Catalyzed C-H Allylation of (Hetero)Arenes with Methyleneoxetanones.
Sign Up to like & getrecommendations! Published in 2017 at "Organic letters"
DOI: 10.1021/acs.orglett.7b02983
Abstract: An efficient synthesis of disubstituted acrylic acids has been realized via Rh(III)-catalyzed C-H activation of (hetero)arenes and coupling with four-membered methyleneoxetanones under redox-neutral conditions. In most cases, the reactions are silver-free, and the products are… read more here.
Keywords: hetero arenes; via iii; access substituted; iii catalyzed ... See more keywords
Nanostructured Carbon Nitride for Continuous-Flow Trifluoromethylation of (Hetero)arenes
Sign Up to like & getrecommendations! Published in 2023 at "ACS Sustainable Chemistry & Engineering"
DOI: 10.1021/acssuschemeng.3c00176
Abstract: Efficient catalytic methods for the trifluoromethylation of (hetero)arenes are of particular importance in organic and pharmaceutical manufacturing. However, many existing protocols rely on toxic reagents and expensive or sterically hindered homogeneous catalysts. One promising alternative… read more here.
Keywords: trifluoromethylation hetero; hetero arenes; continuous flow; carbon nitride ... See more keywords