Regioselective (Hetero)aryl C–H Thianthrenation and Late-Stage Transformations
Sign Up to like & getrecommendations! Published in 2019 at "Chem"
DOI: 10.1016/j.chempr.2019.04.011
Abstract: In their recent report in Nature, Ritter and co-workers took advantage of a persistent sulfur-based radical cation to regioselectively install a thianthrene motif in simple or complex (hetero)arenes, and the resulting thianthrenium salts could undergo… read more here.
Keywords: late stage; hetero aryl; stage transformations; regioselective hetero ... See more keywords
Room Temperature Cu-Catalyzed N-Arylation of Oxazolidinones and Amides with (Hetero)Aryl Iodides.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c00122
Abstract: N,N'-Bis(pyridin-2-ylmethyl)oxalamide (BPMO) was found to be an apposite promoter for the Cu-catalyzed N-arylation of oxazolidinones and primary and secondary amides with (hetero)aryl iodides at room temperature. Excellent chemoselectivity reached between aryl iodides and aryl bromides,… read more here.
Keywords: hetero aryl; amides hetero; aryl iodides; catalyzed arylation ... See more keywords
Copper-Catalyzed Coupling Reaction of (Hetero)Aryl Chlorides and Amides.
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DOI: 10.1021/acs.orglett.7b02326
Abstract: Cu2O/N,N'-bis(thiophen-2-ylmethyl)oxalamide is established to be an effective catalyst system for Goldberg amidation with inferior reactive (hetero)aryl chlorides, which have not been efficiently documented by Cu-catalysis to date. The reaction is well liberalized toward a variety… read more here.
Keywords: hetero aryl; reaction; aryl chlorides; copper catalyzed ... See more keywords
Cu/N,N'-Dibenzyloxalamide-Catalyzed N-Arylation of Heteroanilines.
Sign Up to like & getrecommendations! Published in 2019 at "Organic letters"
DOI: 10.1021/acs.orglett.9b02509
Abstract: N,N'-Dibenzyloxalamide (DBO) was identified as a powerful ligand for promoting Cu-catalyzed coupling of heteroanilines with (hetero)aryl halides. For (hetero)aryl chlorides, the coupling reaction occurred at 130 °C with 5 mol % CuBr and 10 mol… read more here.
Keywords: arylation heteroanilines; hetero aryl; dibenzyloxalamide catalyzed; arylation ... See more keywords
Photochemically-Mediated, Nickel-Catalyzed Synthesis of N-(Hetero)aryl Sulfamate Esters.
Sign Up to like & getrecommendations! Published in 2019 at "Organic letters"
DOI: 10.1021/acs.orglett.9b02621
Abstract: A general method is described for the coupling of (hetero)aryl bromides with O-alkyl sulfamate esters. The protocol relies on catalytic amounts of nickel and photoexcitable iridium complexes and proceeds under visible light irradiation at ambient… read more here.
Keywords: hetero aryl; alkyl sulfamate; sulfamate; sulfamate esters ... See more keywords
Nickel-Catalyzed C–N Cross-Coupling of Ammonia, (Hetero)anilines, and Indoles with Activated (Hetero)aryl Chlorides Enabled by Ligand Design
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DOI: 10.1021/acscatal.9b03715
Abstract: The Ni(II) precatalyst (C1) featuring the phosphonite ancillary ligand Phen-DalPhos (L1) was employed in the cross-coupling of (hetero)anilines with (hetero)aryl chlorides and in the diarylation of... read more here.
Keywords: hetero anilines; hetero aryl; hetero; ligand ... See more keywords
Modular Access to Chiral α-(Hetero)aryl Amines via Ni/Photoredox-Catalyzed Enantioselective Cross-Coupling.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c02795
Abstract: Chiral α-aryl N-heterocycles are commonly found in natural products, pharmaceutical agents, and chiral catalysts but remain challenging to access via asymmetric catalysis. Herein, we report a general and modular approach for the direct enantioselective α-arylation… read more here.
Keywords: hetero aryl; access; aryl; cross coupling ... See more keywords
Dual-role of PtCl2 catalysis in the intramolecular cyclization of (hetero)aryl-allenes for the facile construction of substituted 2,3-dihydropyrroles and polyheterocyclic skeletons.
Sign Up to like & getrecommendations! Published in 2017 at "Chemical communications"
DOI: 10.1039/c7cc01684k
Abstract: A Pt(ii)-catalyzed cyclization of (hetero)aryl-allenes has been developed, providing controllable synthesis of substituted 2,3-dihydropyrroles and polyheterocyclic skeletons. Another notable feature of this method is the dual-role of the Pt(ii) catalyst: initiation of the migration of… read more here.
Keywords: aryl allenes; cyclization hetero; dihydropyrroles polyheterocyclic; hetero aryl ... See more keywords
Electrosynthesis of (hetero)aryl nitriles from α-imino-oxy acids via oxidative decarboxylation/N-O cleavage.
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DOI: 10.1039/d2cc02986c
Abstract: A new method for the synthesis of (hetero)aryl nitriles via iminyl radicals has been developed through the electrochemical oxidative decarboxylation of α-imino-oxy acids. This protocol provides an efficient approach to nitriles with a broad range… read more here.
Keywords: hetero aryl; imino oxy; oxy acids; oxidative decarboxylation ... See more keywords
Recent advances in the synthesis of 5-(hetero)aryl uracil derivatives
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DOI: 10.1055/a-2091-1071
Abstract: C5-Aryl/heteroaryl uracil-based compounds have attracted continuous interest because of their wide biological potential. In this review we outlined the primary synthetic methods used to prepare designated uracils, all of which were often combined to synthesize… read more here.
Keywords: hetero aryl; hetero; aryl; synthesis hetero ... See more keywords