PdII‐Catalyzed γ‐C(sp3)–H (Hetero)arylation of Ketones Using Acetohydrazide as the Transient Directing Group
Sign Up to like & getrecommendations! Published in 2025 at "Asian Journal of Organic Chemistry"
DOI: 10.1002/ajoc.202500289
Abstract: Pd(II)‐catalyzed γ‐C(sp3)–H (hetero)arylation of aliphatic ketones is developed using acetohydrazide as the transient directing group (TDG). The reaction is facilitated by a crucial 2‐pyridone ligand via the 5,6‐membered fused palladacycle intermediate, enabling the smooth γ‐C(sp3)–H… read more here.
Keywords: catalyzed sp3; sp3 hetero; arylation; hetero arylation ... See more keywords
Fe-Catalyzed Fluoroalkyl(hetero)arylation of Vinyl Azaarenes: Rapid and Modular Synthesis of Unsymmetrical 1,1-Bis(hetero)arylalkanes
Sign Up to like & getrecommendations! Published in 2024 at "Organic Letters"
DOI: 10.1021/acs.orglett.4c02515
Abstract: In contrast to transition-metal-catalyzed difunctionalization of activated alkenes, selective alkylarylation of vinyl azaarenes is underdeveloped. Consequently, the lack of modular and rapid syntheses of 1,1-bis(hetero)arylalkanes limits their exploration in medicinal chemistry. Herein we report a… read more here.
Keywords: hetero arylation; bis hetero; hetero arylalkanes; fluoroalkyl hetero ... See more keywords
Palladium-Catalyzed Regio- and Diastereoselective Hydro(hetero)arylation for Rapid Construction of Quaternary Center Containing Cyclobutanes.
Sign Up to like & getrecommendations! Published in 2024 at "Organic letters"
DOI: 10.1021/acs.orglett.4c02645
Abstract: Herein we report a Pd-catalyzed regio- and diastereoselective hydro(hetero)arylation of inactivated alkylidenecyclobutanes. This protocol provides a rapid and atom-economical route to access 3-cyclobutyl (hetero)arenes with good functionalities toleration. With the assistance of the directing group,… read more here.
Keywords: hetero arylation; catalyzed regio; hydro hetero; diastereoselective hydro ... See more keywords
Regioselective 1,2-Di(hetero)arylation of Activated and Unactivated Alkenes with (Hetero)aryl Chlorides.
Sign Up to like & getrecommendations! Published in 2025 at "Organic letters"
DOI: 10.1021/acs.orglett.5c01269
Abstract: Aryl chlorides are more commercially available and lower cost compared with aryl bromides and iodides. However, the use of (hetero)aryl chlorides as aryl radical precursors for the di(hetero)arylation of alkenes remains an underdeveloped area. Furthermore,… read more here.
Keywords: hetero; hetero arylation; aryl chlorides; hetero aryl ... See more keywords
Photoinduced EDA Complexes Enabled C3 (Hetero)arylation of Indoles Using Amine as a Transient Occupying Group.
Sign Up to like & getrecommendations! Published in 2025 at "Organic letters"
DOI: 10.1021/acs.orglett.5c03052
Abstract: Herein, an EDA complex enabled selective C3 (hetero)arylation of indole was established, utilizing morpholine as the transient occupying group. This protocol is efficient, sustainable, and exhibits excellent substrate compatibility and functional group tolerance. Mechanistic studies… read more here.
Keywords: hetero arylation; group; eda; occupying group ... See more keywords
Cobalt-Catalyzed Decarboxylative C-H (Hetero)Arylation for the Synthesis of Arylheteroarenes and Unsymmetrical Biheteroaryls.
Sign Up to like & getrecommendations! Published in 2017 at "Organic letters"
DOI: 10.1021/acs.orglett.7b02730
Abstract: A cobalt-catalyzed decarboxylative cross-coupling reaction of (hetero)aryl carboxylic acids with benzothiazoles or benzoxazoles is reported. This represents a first example of metal-catalyzed decarboxylative C-H heteroarylation of benzo-fused heterocycles. The transformation provides a convenient route, with… read more here.
Keywords: arylation synthesis; catalyzed decarboxylative; cobalt catalyzed; decarboxylative hetero ... See more keywords
Soluble phenylenedioxythiophene copolymers via direct (hetero)arylation polymerization: a revived monomer for organic electronics
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Materials Chemistry C"
DOI: 10.1039/c7tc05293f
Abstract: Dioxyheterocycles, particularly 3,4-ethylenedioxythiophene (EDOT), have proven to be useful building blocks for conjugated materials targeting various applications. The 3,4-phenylenedioxythiophene (PheDOT) unit is similar to the EDOT unit in terms of planarity and steric interactions, but… read more here.
Keywords: via direct; direct hetero; arylation polymerization; hetero arylation ... See more keywords
Dithienophosphole-based molecular electron acceptors constructed using direct (hetero)arylation cross-coupling methods
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Materials Chemistry C"
DOI: 10.1039/c7tc05631a
Abstract: Herein we report on the first successful coupling of the dithienophosphole (S2PO) functional building block with three types of heteroaryl end caps using direct (hetero)arylation C–H bond functionalization methods. As a model reaction, S2PO was… read more here.
Keywords: dithienophosphole based; direct hetero; using direct; hetero arylation ... See more keywords