An investigation of molecular mechanism and the role of Te-bridged-atom in the formation of polysubstituted pyridines via Hetero-Diels–Alder reaction of isotellurazole with acetylenic dienophile: a molecular electron density study
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Chemical Sciences"
DOI: 10.1007/s12039-018-1459-7
Abstract: An electron localization function (ELF) analysis and a detailed computational study of the hetero-Diels-Alder (HDA) reaction between isotellurazole and acetylenic dienophile have been performed. Then, B3LYP/Lanl2dz + 6-31+g(d) basis set level has been used to… read more here.
Keywords: reaction isotellurazole; diels alder; mechanism; hetero diels ... See more keywords
Hetero-Diels-Alder reactions of novel 3-triazolyl-nitrosoalkenes as an approach to functionalized 1,2,3-triazoles with antibacterial profile.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2017.11.052
Abstract: The generation and reactivity of 3-triazolyl-nitrosoalkenes are reported for the first time. The study showed that hetero-Diels-Alder reaction of these heterodienes is an interesting synthetic strategy to functionalized 1,2,3-triazoles, including 1,2,3-triazolyl-pyrroles, 1,2,3-triazolyl-dipyrromethanes and 1,2,3-triazolyl-indoles. The… read more here.
Keywords: diels alder; antibacterial profile; hetero diels; functionalized triazoles ... See more keywords
Nitrosocarbonyl hetero-Diels–Alder cycloaddition with 2-substituted 1,3-butadienes
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DOI: 10.1016/j.tet.2016.11.046
Abstract: Abstract A study of the reactivity of 2-substituted 1,3-butadienes with nitrosocarbonyl compounds in the 4+2 cycloaddition has been carried out showing that the regioselectivity involves a delicate balance of steric and electronic effects. 2-Aryl 1,3-butadienes… read more here.
Keywords: cycloaddition; diels alder; substituted butadienes; hetero diels ... See more keywords
Catalytic Diastereoselective Hetero-Diels-Alder Reaction of α-Haloacroleins with Alkenes: Construction of 3,4-Dihydropyran.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c00341
Abstract: In this Letter, a catalytic diastereoselective hetero-Diels-Alder reaction of α-haloacroleins with less polarized alkenes was developed, and the resulting 3,4-dihydropyrans were produced in high yields with a broad substate scope. Mechanism studies showed that 3,4-dihydropyran… read more here.
Keywords: catalytic diastereoselective; diels alder; reaction haloacroleins; diastereoselective hetero ... See more keywords
An Integrated Building Block for Cascade Diels-Alder and Hetero-Diels-Alder Reactions.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c00774
Abstract: The Diels-Alder (DA) reaction and hetero-Diels-Alder (HDA) reaction are among the most powerful methods for the construction of carbocycles and heterocycles. Herein, an integrated building block of DA and HDA reactions is described. The triazenyl… read more here.
Keywords: reaction; integrated building; diels alder; building block ... See more keywords
Total Synthesis of (±)-Pestalachloride C and (±)-Pestalachloride D through a Biomimetic Knoevenagel/Hetero-Diels-Alder Cascade.
Sign Up to like & getrecommendations! Published in 2019 at "Organic letters"
DOI: 10.1021/acs.orglett.9b00323
Abstract: A concise total synthesis of (±)-pestalachloride C and (±)-pestalachloride D was achieved through a Knoevenagel/hetero-Diels-Alder cascade reaction to test the nonenzymatic biosynthetic hypothesis of Shao, Wang, and co-workers. The cascade reaction generates a mixture of… read more here.
Keywords: synthesis pestalachloride; pestalachloride; hetero diels; total synthesis ... See more keywords
Iron-Catalyzed Enantioselective Intramolecular Inverse Electron-Demand Hetero Diels-Alder Reactions: An Access to Bicyclic Dihydropyran Derivatives.
Sign Up to like & getrecommendations! Published in 2019 at "Organic letters"
DOI: 10.1021/acs.orglett.9b03752
Abstract: A highly enantioselective iron-catalyzed Intramolecular Inverse Electron-Demand Hetero Diels-Alder (IIEDHDA) reaction is reported. By using a chiral semicorrin ligand in the presence of 2,6-lutidine, good isolated yields and excellent enantioselectivities were observed (up to 96%… read more here.
Keywords: demand hetero; intramolecular inverse; hetero diels; iron catalyzed ... See more keywords
Organocatalytic Asymmetric Dearomatizing Hetero-Diels-Alder Reaction of Nonactivated Arenes.
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DOI: 10.1021/jacs.2c01106
Abstract: Nonactivated arenes, such as benzene derivatives, are chemically inert due to their intrinsic aromaticity and low polarity. The catalytic asymmetric dearomatization (CADA, coined by You and co-workers) of the nonactivated arenes represents a formidable challenge.… read more here.
Keywords: organocatalytic asymmetric; asymmetric dearomatizing; reaction; hetero diels ... See more keywords
Unusual KIE and dynamics effects in the Fe-catalyzed hetero-Diels-Alder reaction of unactivated aldehydes and dienes
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DOI: 10.1038/s41467-020-15599-w
Abstract: Hetero-Diels-Alder (HDA) reaction is an important synthetic method for many natural products. An iron(III) catalyst was developed to catalyze the challenging HDA reaction of unactivated aldehydes and dienes with high selectivity. Here we report extensive density-functional… read more here.
Keywords: diels alder; kie; hetero diels; unactivated aldehydes ... See more keywords
Synthesis and hetero-Diels-Alder reactions of enantiomerically pure dihydro-1H-azepines.
Sign Up to like & getrecommendations! Published in 2020 at "Chemical communications"
DOI: 10.1039/d0cc04413j
Abstract: Thermolysis of enantiomerically pure 3-substituted 7,7-dihalo-2-azabicyclo[4.1.0]heptanes in the presence of K2CO3 gives in good yields 2-alkyl-6-halo-1-tosyl-2,3-dihydro-1H-azepines. These undergo highly stereoselective [4+2] cycloaddition reactions with heterodienophiles and arylation/alkenylation under Suzuki conditions. read more here.
Keywords: diels alder; dihydro azepines; hetero diels; synthesis hetero ... See more keywords
Hetero-Diels–Alder reactions of 2H-phospholes with allenes: synthesis and functionalization of 6-methylene-1-phosphanorbornenes
Sign Up to like & getrecommendations! Published in 2021 at "Organic chemistry frontiers"
DOI: 10.1039/d1qo00535a
Abstract: The phospha-Diels–Alder reaction between 2H-phospholes and arylallenes affords 6-methylene-1-phosphanorbornenes in high yields with excellent regioselectivity. This Diels–Alder reaction proceeds at the internal CC double bond of allenes selectively. DFT calculations of possible transition states finely… read more here.
Keywords: reactions phospholes; diels alder; alder reactions; hetero diels ... See more keywords