Palladium-Catalyzed [5 + 2] Heteroannulation of Phenethylamides with 1,3-Dienes to Dopaminergic 3-Benzazepines.
Sign Up to like & getrecommendations! Published in 2020 at "Organic letters"
DOI: 10.1021/acs.orglett.0c01053
Abstract: Phenethyltriflamides react with 1,3-dienes upon treatment with a catalytic amount of Pd(OAc)2 and Cu(OAc)2/O2 as oxidant to afford chemo-, regio- and diastereoselectively 2,3,4,5-tetrahydro-1H-benzo[d]azepines (3-benzazepine derivatives) in good to excellent yields. A DFT study of the… read more here.
Keywords: heteroannulation phenethylamides; dienes dopaminergic; heteroannulation; palladium catalyzed ... See more keywords
Synthesis of 2-BMIDA Indoles via Heteroannulation: Applications in Drug Scaffold and Natural Product Synthesis
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DOI: 10.1021/acs.orglett.2c00959
Abstract: A Pd-catalyzed heteroannulation approach for the synthesis of C2 borylated indoles is reported. The process allows access to highly functionalized 2-borylated indole scaffolds with complete control of regioselectivity. The utility of the process is demonstrated… read more here.
Keywords: synthesis bmida; synthesis; bmida indoles; heteroannulation ... See more keywords
Palladium-catalyzed synthesis of [60]fullerene-fused benzofurans via heteroannulation of phenols.
Sign Up to like & getrecommendations! Published in 2017 at "Chemical communications"
DOI: 10.1039/c6cc09080j
Abstract: Palladium-catalyzed heteroannulation of [60]fullerene with phenols has been developed as a practical and efficient protocol for the one-pot synthesis of various [60]fullerene-fused benzofurans. A possible reaction mechanism is proposed to explain the formation of C60-fused… read more here.
Keywords: fused benzofurans; fullerene fused; fullerene; heteroannulation ... See more keywords
Stereospecific nickel-catalyzed [4+2] heteroannulation of alkynes with aminophosphanes
Sign Up to like & getrecommendations! Published in 2023 at "Science Advances"
DOI: 10.1126/sciadv.ade8638
Abstract: Enantioenriched phosphorus compounds play crucial roles in many fields ranging from catalyst to materials science to drug development. Despite advances in the construction of phosphacycles, incorporation of a P-chirogenic center into heterocycles remains challenging. Here,… read more here.
Keywords: stereospecific nickel; nickel catalyzed; heteroannulation alkynes; heteroannulation ... See more keywords