Heteroaromatic swapping in aromatic ketones
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DOI: 10.1038/s41467-025-64041-6
Abstract: The modification of aromatic rings to heteroaromatic rings is a widely employed strategy in medicinal chemistry, often used to modulate lipophilicity and improve metabolic stability. However, achieving a one-step, generalizable transformation of aromatic rings into… read more here.
Keywords: chemistry; aromatic rings; rings heteroaromatic; heteroaromatic rings ... See more keywords
‘Heteroaromatic Rings of the Future’: Exploration of Unconquered Chemical Space
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DOI: 10.1055/s-0037-1611279
Abstract: William Pitt and co-workers have created a virtual exploratory heterocyclic library ‘VEHICLe’ containing over 200 unconquered bicyclic heteroaromatic rings, synthetically feasible with potential medicinal interest. Since the publication of the 22 ‘heteroaromatic rings of the… read more here.
Keywords: rings future; pyridin one; oxazin one; heteroaromatic rings ... See more keywords