Pd-Catalyzed Amination of Base-Sensitive Five-Membered Heteroaryl Halides with Aliphatic Amines.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c13520
Abstract: We report a versatile and functional-group-tolerant method for the Pd-catalyzed C-N cross-coupling of five-membered heteroaryl halides with primary and secondary amines, an important but underexplored transformation. Coupling reactions of challenging, pharmaceutically relevant heteroarenes, such as… read more here.
Keywords: five membered; membered heteroaryl; heteroaryl halides; sensitive five ... See more keywords
Nickel-Catalyzed Electrochemical Reductive Homocouplings of Aryl and Heteroaryl Halides: A Useful Route to Symmetrical Biaryls
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DOI: 10.1055/s-0036-1589100
Abstract: Due to their widespread presence in functional materials and pharmaceuticals, biaryls are of fundamental importance in organic chemistry. Methods for the synthesis of symmetrical biaryls generally involve both metallic reduction and transition-metal catalysis. In this… read more here.
Keywords: biaryls; symmetrical biaryls; aryl heteroaryl; heteroaryl halides ... See more keywords
Nickel-Catalyzed Cross-Coupling of Functionalized Organomanganese Reagents with Aryl and Heteroaryl Halides Promoted by 4-Fluorostyrene
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DOI: 10.1055/s-0036-1589101
Abstract: A catalytic system consisting of Ni(acac)2 (5 mol%) and 4-fluorostyrene (20 mol%) allows a convenient cross-coupling of functionalized organomanganese reagents with a variety of aryl and heteroaryl halides leading to polyfunctionalized diaryl- and arylheteroarylmethane derivatives. read more here.
Keywords: coupling functionalized; aryl heteroaryl; heteroaryl halides; nickel catalyzed ... See more keywords