The 19S proteasome regulates subtelomere silencing and facultative heterochromatin formation in fission yeast
Sign Up to like & getrecommendations! Published in 2017 at "Current Genetics"
DOI: 10.1007/s00294-017-0792-6
Abstract: Accumulating evidence shows that non-proteolytic functions of the proteasome are as crucial as its well-known proteolytic function in regulating cellular activities. In our recent work, we showed that the 19S proteasome mediates the heterochromatin spreading… read more here.
Keywords: heterochromatin; 19s proteasome; subtelomere silencing; silencing facultative ... See more keywords
Proteomic profiling of yeast heterochromatin connects direct physical and genetic interactions
Sign Up to like & getrecommendations! Published in 2018 at "Current Genetics"
DOI: 10.1007/s00294-018-0889-6
Abstract: Heterochromatin domains are stably repressed chromatin structures composed of a core assembly of silencing proteins that condense adjacent nucleosomes. The minimal heterochromatin structure can serve as a platform for recruitment of complementary regulatory factors. We… read more here.
Keywords: heterochromatin; proteomic profiling; profiling yeast; yeast heterochromatin ... See more keywords
Evolutionary convergence or homology? Comparative cytogenomics of Caesalpinia group species (Leguminosae) reveals diversification in the pericentromeric heterochromatic composition
Sign Up to like & getrecommendations! Published in 2019 at "Planta"
DOI: 10.1007/s00425-019-03287-z
Abstract: Main conclusionWe demonstrated by cytogenomic analysis that the proximal heterochromatin of the Northeast Brazilian species of Caesalpinia group is enriched with phylogenetically conserved Ty3/Gypsy-Tekay RT, but diverge in the presence of Ty3/Gypsy-Athila RT and satDNA.AbstractThe… read more here.
Keywords: heterochromatin; ty3 gypsy; group; composition ... See more keywords
Liquid-like interactions in heterochromatin: Implications for mechanism and regulation.
Sign Up to like & getrecommendations! Published in 2020 at "Current opinion in cell biology"
DOI: 10.1016/j.ceb.2020.03.004
Abstract: A large portion of the eukaryotic genome is packed into heterochromatin, a versatile platform that is essential to maintain genome stability. Often associated with a compact and transcriptionally repressed chromatin state, heterochromatin was earlier considered… read more here.
Keywords: heterochromatin; like interactions; heterochromatin implications; interactions heterochromatin ... See more keywords
The Conserved RNA Binding Cyclophilin, Rct1, Regulates Small RNA Biogenesis and Splicing Independent of Heterochromatin Assembly.
Sign Up to like & getrecommendations! Published in 2017 at "Cell reports"
DOI: 10.1016/j.celrep.2017.05.086
Abstract: RNAi factors and their catalytic activities are essential for heterochromatin assembly in S. pombe. This has led to the idea that siRNAs can promote H3K9 methylation by recruiting the cryptic loci regulator complex (CLRC), also known… read more here.
Keywords: heterochromatin; rna binding; heterochromatin assembly; conserved rna ... See more keywords
Dense Transposon Integration Reveals Essential Cleavage and Polyadenylation Factors Promote Heterochromatin Formation.
Sign Up to like & getrecommendations! Published in 2020 at "Cell reports"
DOI: 10.1016/j.celrep.2020.01.094
Abstract: Heterochromatin functions as a scaffold for factors responsible for gene silencing and chromosome segregation. Heterochromatin can be assembled by multiple pathways, including RNAi and RNA surveillance. We identified factors that form heterochromatin using dense profiles… read more here.
Keywords: polyadenylation factors; heterochromatin; cleavage polyadenylation; integration ... See more keywords
The ApiAP2 factor PfAP2-HC is an integral component of heterochromatin in the malaria parasite Plasmodium falciparum
Sign Up to like & getrecommendations! Published in 2021 at "iScience"
DOI: 10.1016/j.isci.2021.102444
Abstract: Summary Malaria parasites undergo a complex life cycle in the human host and the mosquito vector. The ApiAP2 family of DNA-binding proteins plays a dominant role in parasite development and life cycle progression. Most ApiAP2… read more here.
Keywords: heterochromatin; malaria; plasmodium falciparum; apiap2 factor ... See more keywords
Schistosoma mansoni Heterochromatin Protein 1 (HP1) nuclear interactome in cercariae.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of proteomics"
DOI: 10.1016/j.jprot.2021.104170
Abstract: Schistosoma mansoni causes schistosomiasis, which affects 240 million people, and 700 million people are living at risk of infection. Epigenetic mechanisms are important for transcriptional control and are well-known conserved transcriptional co-regulators in evolution, already… read more here.
Keywords: protein; heterochromatin; cercariae; schistosoma mansoni ... See more keywords
The Role of Phase Separation in Heterochromatin Formation, Function, and Regulation.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemistry"
DOI: 10.1021/acs.biochem.8b00401
Abstract: In eukaryotic cells, structures called heterochromatin play critical roles in nuclear processes ranging from gene repression to chromosome segregation. Biochemical and in vivo studies over the past several decades have implied that the diverse functions… read more here.
Keywords: phase separation; heterochromatin; separation heterochromatin; role phase ... See more keywords
Multivalent Peptide Ligands To Probe the Chromocenter Microenvironment in Living Cells.
Sign Up to like & getrecommendations! Published in 2022 at "ACS chemical biology"
DOI: 10.1021/acschembio.2c00203
Abstract: Chromatin is spatially organized into functional states that are defined by both the presence of specific histone post-translational modifications (PTMs) and a defined set of chromatin-associated "reader" proteins. Different models for the underlying mechanism of… read more here.
Keywords: chromatin; ligands probe; microenvironment; multivalent peptide ... See more keywords
MAP2K6 remodels chromatin and facilitates reprogramming by activating Gatad2b-phosphorylation dependent heterochromatin loosening.
Sign Up to like & getrecommendations! Published in 2021 at "Cell death and differentiation"
DOI: 10.1038/s41418-021-00902-z
Abstract: Somatic cell reprogramming is an ideal model for studying epigenetic regulation as it undergoes dramatic chromatin remodeling. However, a role for phosphorylation signaling in chromatin protein modifications for reprogramming remains unclear. Here, we identified mitogen-activated… read more here.
Keywords: heterochromatin; heterochromatin loosening; map2k6 remodels; remodels chromatin ... See more keywords