N6‐Methyladenosine‐Modified CBX1 Regulates Nasopharyngeal Carcinoma Progression Through Heterochromatin Formation and STAT1 Activation
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202205091
Abstract: Epitranscriptomic remodeling such as N6‐methyladenosine (m6A) modification plays a critical role in tumor development. However, little is known about the underlying mechanisms connecting m6A modification and nasopharyngeal carcinoma (NPC) progression. Here, CBX1 is identified, a… read more here.
Keywords: nasopharyngeal carcinoma; progression; cbx1; modified cbx1 ... See more keywords
Heterochromatin Formation Promotes Antimicrobial Responses in Aging Drosophila
Sign Up to like & getrecommendations! Published in 2017 at "Mechanisms of Development"
DOI: 10.1016/j.mod.2017.04.011
Abstract: APA fetal brains showed decreased expression of genes involved in neuronal differentiation and axon development, compared to controls. APA placentas showed robust changes in gene expression patterns suggestive of altered placental functions. In particular, several… read more here.
Keywords: promotes antimicrobial; formation promotes; expression; fetal brains ... See more keywords
The Role of Phase Separation in Heterochromatin Formation, Function, and Regulation.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemistry"
DOI: 10.1021/acs.biochem.8b00401
Abstract: In eukaryotic cells, structures called heterochromatin play critical roles in nuclear processes ranging from gene repression to chromosome segregation. Biochemical and in vivo studies over the past several decades have implied that the diverse functions… read more here.
Keywords: phase separation; heterochromatin; separation heterochromatin; role phase ... See more keywords
Plant HP1 protein ADCP1 links multivalent H3K9 methylation readout to heterochromatin formation
Sign Up to like & getrecommendations! Published in 2018 at "Cell Research"
DOI: 10.1038/s41422-018-0104-9
Abstract: Heterochromatin Protein 1 (HP1) recognizes histone H3 lysine 9 methylation (H3K9me) through its conserved chromodomain and maintains heterochromatin from fission yeast to mammals. However, in Arabidopsis, Like Heterochromatin Protein 1 (LHP1) recognizes and colocalizes genome-wide… read more here.
Keywords: protein; heterochromatin; methylation; hp1 ... See more keywords
FAST-1 antisense RNA epigenetically alters FXN expression
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-35639-2
Abstract: Friedreich ataxia (FRDA) is a multisystem genetic disorder caused by GAA repeat expansion mutations within the FXN gene, resulting in heterochromatin formation and deficiency of frataxin protein. Elevated levels of the FXN antisense transcript (FAST-1)… read more here.
Keywords: fast frda; expression fast; expression; fxn expression ... See more keywords
Integrity of a heterochromatic domain ensured by its boundary elements
Sign Up to like & getrecommendations! Published in 2020 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2010062117
Abstract: Significance The fission yeast silent mating-type region provides an excellent system to ask how chromatic domains with opposite effects on gene expression coexist side by side along chromosomes and to investigate roles played by DNA… read more here.
Keywords: boundary elements; domain ensured; integrity heterochromatic; heterochromatic domain ... See more keywords
Facultative heterochromatin formation in rDNA is essential for cell survival during nutritional starvation
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac175
Abstract: Abstract During the cellular adaptation to nutrient starvation, cells temporarily decelerate translation processes including ribosomal biogenesis. However, the mechanisms repressing robust gene expression from the ribosomal gene cluster (rDNA) are unclear. Here, we demonstrate that… read more here.
Keywords: heterochromatin; facultative heterochromatin; starvation; formation rdna ... See more keywords
Regulated nuclear accumulation of a histone methyltransferase times the onset of heterochromatin formation in C. elegans embryos
Sign Up to like & getrecommendations! Published in 2018 at "Science Advances"
DOI: 10.1126/sciadv.aat6224
Abstract: MET-2/SETDB1 and interactors LIN-65/ATF7IP and ARLE-14/ARL14EP initiate heterochromatin formation during embryogenesis. Heterochromatin formation during early embryogenesis is timed precisely, but how this process is regulated remains elusive. We report the discovery of a histone methyltransferase… read more here.
Keywords: histone methyltransferase; nuclear accumulation; heterochromatin formation; formation ... See more keywords