Complete loss of H3K9 methylation dissolves mouse heterochromatin organization
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DOI: 10.1038/s41467-021-24532-8
Abstract: Histone H3 lysine 9 (H3K9) methylation is a central epigenetic modification that defines heterochromatin from unicellular to multicellular organisms. In mammalian cells, H3K9 methylation can be catalyzed by at least six distinct SET domain enzymes:… read more here.
Keywords: heterochromatin organization; methylation; h3k9 methylation; set domain ... See more keywords
Lysine 27 dimethylation of Drosophila linker histone dH1 contributes to heterochromatin organization independently of H3K9 methylation
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac716
Abstract: Abstract Post-translational modifications (PTMs) of core histones are important epigenetic determinants that correlate with functional chromatin states. However, despite multiple linker histone H1s PTMs have been identified, little is known about their genomic distribution and… read more here.
Keywords: h3k9 methylation; methylation; heterochromatin organization; linker histone ... See more keywords
SCML2 promotes heterochromatin organization in late spermatogenesis
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DOI: 10.1242/jcs.217125
Abstract: ABSTRACT Spermatogenesis involves the progressive reorganization of heterochromatin. However, the mechanisms that underlie the dynamic remodeling of heterochromatin remain unknown. Here, we identify SCML2, a germline-specific Polycomb protein, as a critical regulator of heterochromatin organization… read more here.
Keywords: spermatogenesis; heterochromatin organization; scml2; expression ... See more keywords
MeCP2 heterochromatin organization is modulated by arginine methylation and serine phosphorylation
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.941493
Abstract: Rett syndrome is a human intellectual disability disorder that is associated with mutations in the X-linked MECP2 gene. The epigenetic reader MeCP2 binds to methylated cytosines on the DNA and regulates chromatin organization. We have… read more here.
Keywords: heterochromatin; mecp2 heterochromatin; rett syndrome; phosphorylation ... See more keywords