The histone chaperone FACT facilitates heterochromatin spreading by regulating histone turnover and H3K9 methylation states
Sign Up to like & getrecommendations! Published in 2021 at "Cell reports"
DOI: 10.1016/j.celrep.2021.109944
Abstract: SUMMARY Heterochromatin formation requires three distinct steps: nucleation, self-propagation (spreading) along the chromosome, and faithful maintenance after each replication cycle. Impeding any of those steps induces heterochromatin defects and improper gene expression. The essential histone… read more here.
Keywords: histone chaperone; histone turnover; heterochromatin spreading; fact ... See more keywords
H3K56 deacetylation and H2A.Z deposition are required for aberrant heterochromatin spreading
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac196
Abstract: Abstract Crucial mechanisms are required to restrict self-propagating heterochromatin spreading within defined boundaries and prevent euchromatic gene silencing. In the filamentous fungus Neurospora crassa, the JmjC domain protein DNA METHYLATION MODULATOR-1 (DMM-1) prevents aberrant spreading… read more here.
Keywords: aberrant heterochromatin; heterochromatin; aberrant spreading; domain ... See more keywords
Local chromatin context regulates the genetic requirements of the heterochromatin spreading reaction
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Genetics"
DOI: 10.1371/journal.pgen.1010201
Abstract: Heterochromatin spreading, the expansion of repressive chromatin structure from sequence-specific nucleation sites, is critical for stable gene silencing. Spreading re-establishes gene-poor constitutive heterochromatin across cell cycles but can also invade gene-rich euchromatin de novo to… read more here.
Keywords: heterochromatin; nucleation; gene silencing; heterochromatin spreading ... See more keywords