Heterochronic parabiosis regulates the extent of cellular senescence in multiple tissues
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DOI: 10.1007/s11357-020-00185-1
Abstract: An increase in the burden of senescent cells in tissues with age contributes to driving aging and the onset of age-related diseases. Genetic and pharmacologic elimination of senescent cells extends both health span and life… read more here.
Keywords: senescence; parabiosis regulates; multiple tissues; heterochronic parabiosis ... See more keywords
Application of bio-orthogonal proteome labeling to cell transplantation and heterochronic parabiosis
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DOI: 10.1038/s41467-017-00698-y
Abstract: Studies of heterochronic parabiosis demonstrated that with age, the composition of the circulatory milieu changes in ways that broadly inhibit tissue regenerative capacity. In addition, local tissue niches have age-specific influences on their resident stem… read more here.
Keywords: orthogonal proteome; bio orthogonal; parabiosis; chemistry ... See more keywords
Addendum: Application of bio-orthogonal proteome labeling to cell transplantation and heterochronic parabiosis
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/s41467-017-02779-4
Abstract: Studies of heterochronic parabiosis demonstrated that with age, the composition of the circulatory milieu changes in ways that broadly inhibit tissue regenerative capacity. In addition, local tissue niches have age-specific influences on their resident stem… read more here.
Keywords: orthogonal proteome; bio orthogonal; parabiosis; chemistry ... See more keywords
Molecular hallmarks of heterochronic parabiosis at single-cell resolution.
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DOI: 10.1038/s41586-022-04461-2
Abstract: The ability to slow or reverse biological ageing would have major implications for mitigating disease risk and maintaining vitality1. Although an increasing number of interventions show promise for rejuvenation2, their effectiveness on disparate cell types… read more here.
Keywords: single cell; heterochronic parabiosis; cell; parabiosis ... See more keywords
Heterochronic Parabiosis Causes Dacryoadenitis in Young Lacrimal Glands
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DOI: 10.3390/ijms24054897
Abstract: Aging is associated with inflammation and oxidative stress in the lacrimal gland (LG). We investigated if heterochronic parabiosis of mice could modulate age-related LG alterations. In both males and females, there were significant increases in… read more here.
Keywords: heterochronic parabiosis; inflammation; young lgs; parabiosis ... See more keywords