Palladium-Catalyzed Cascade Reaction Involving Cyclopropenones Enables Construction of Heterocycle-Containing γ-alkylidenebutenolides.
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DOI: 10.1021/acs.orglett.5c03595
Abstract: A novel palladium-catalyzed cascade reaction process for the diverse synthesis of heterocycle-containing γ-alkylidenebutenolide frameworks has been developed. Using this protocol, γ-alkylidenebutenolide and δ-heterocycle units can be constructed simultaneously through one-pot multiple C-C/C-O bond formation of… read more here.
Keywords: containing alkylidenebutenolides; heterocycle containing; palladium catalyzed; heterocycle ... See more keywords
Heterocycle-containing tranylcypromine derivatives endowed with high anti-LSD1 activity
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Enzyme Inhibition and Medicinal Chemistry"
DOI: 10.1080/14756366.2022.2052869
Abstract: Abstract As regioisomers/bioisosteres of 1a, a 4-phenylbenzamide tranylcypromine (TCP) derivative previously disclosed by us, we report here the synthesis and biological evaluation of some (hetero)arylbenzoylamino TCP derivatives 1b-6, in which the 4-phenyl moiety of 1a… read more here.
Keywords: derivatives endowed; containing tranylcypromine; heterocycle containing; endowed high ... See more keywords