Heterocycles–Containing HDAC Inhibitors Active in Cancer: An Overview of the Last Fifteen Years
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DOI: 10.1002/cmdc.202400194
Abstract: Cancer is one of the primary causes of mortality worldwide. Despite nowadays are numerous therapeutic treatments to fight tumor progression, it is still challenging to completely overcome it. It is known that Histone Deacetylases (HDACs),… read more here.
Keywords: cancer; heterocycles containing; active cancer; hdac inhibitors ... See more keywords
Cascade reactions for constructing heterocycles containing a pyrimidino-pyrazino-pyrimidine core using 1,2,4-triazole scaffolds
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DOI: 10.1016/j.tetlet.2019.151089
Abstract: Abstract The regioselective cyclocondensation of aminoethyl-1,2,4-triazoles and glyoxal provides pentacyclic heterocycles in which two 7,8-dihydro-5H-6λ2-[1,2,4]triazolo[1,5-c]pyrimidine systems are connected through CH(OH) bridges generating a central piperazine-2,5-diol ring. The structure of the new compounds was elucidated based… read more here.
Keywords: containing pyrimidino; cascade reactions; reactions constructing; pyrimidine ... See more keywords
A newly designed heterodiene and its application to construct six-membered heterocycles containing an N-O bond.
Sign Up to like & getrecommendations! Published in 2019 at "Chemical communications"
DOI: 10.1039/c9cc05694g
Abstract: A new type of zwitterionic nitrosoalkene generated in situ from dehydrohalogenation of α-halo-N-alkylhydroxamic acids was designed. [4+2] cycloadditions of this heterodiene to olefins provide a facile route to construct six-membered heterocycles containing an N-O bond… read more here.
Keywords: six membered; membered heterocycles; construct six; heterocycles containing ... See more keywords
Multicomponent Synthesis of Potentially Biologically Active Heterocycles Containing a Phosphonate or a Phosphine Oxide Moiety.
Sign Up to like & getrecommendations! Published in 2022 at "Acta chimica Slovenica"
DOI: 10.17344/acsi.2022.7648
Abstract: Several multicomponent synthetic approaches were elaborated for plenty of novel nitrogen or oxygen heterocycles containing a phosphonate or a phosphine oxide moiety. All multicomponent reactions were optimized through a model reaction in respect of the… read more here.
Keywords: phosphonate phosphine; heterocycles containing; containing phosphonate; multicomponent ... See more keywords