Synthesis and structure-activity relationship of tyrosinase inhibiting novel bi-heterocyclic acetamides: Mechanistic insights through enzyme inhibition, kinetics and computational studies.
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DOI: 10.1016/j.bioorg.2019.01.036
Abstract: The present research was designed for the selective synthesis of novel bi-heterocyclic acetamides, 9a-n, and their tyrosinase inhibition to overwhelm the problem of melanogenesis. The structures of newly synthesized compounds were confirmed by spectral techniques… read more here.
Keywords: heterocyclic acetamides; inhibition; novel heterocyclic; tyrosinase ... See more keywords