Synthesis and Pharmacological Activities of Chalcone and Its Derivatives Bearing N-Heterocyclic Scaffolds: A Review
Sign Up to like & getrecommendations! Published in 2023 at "ACS Omega"
DOI: 10.1021/acsomega.3c01035
Abstract: The incorporation of heterocyclic moieties into the standard chemical structure with a biologically active scaffold has become of crucial practice for the construction of pharmacologically potent candidates in the drug arena. Currently, numerous kinds of… read more here.
Keywords: chalcone derivatives; bearing heterocyclic; pharmacological activities; heterocyclic scaffolds ... See more keywords
MW-9, a chalcones derivative bearing heterocyclic moieties, attenuates experimental autoimmune encephalomyelitis via suppressing pathogenic TH17 cells
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Medicine Reports"
DOI: 10.3892/mmr.2022.12824
Abstract: Previous studies have indicated that MW-9, a chalcones derivative bearing heterocyclic moieties, has considerable anti-inflammatory activity in vitro. Whether MW-9 may be used to treat inflammation-based diseases, such as multiple sclerosis, remains unknown. The present… read more here.
Keywords: derivative bearing; th17 cells; chalcones derivative; bearing heterocyclic ... See more keywords
Purine derivatives with heterocyclic moieties and related analogs as new antitumor agents.
Sign Up to like & getrecommendations! Published in 2019 at "Future medicinal chemistry"
DOI: 10.4155/fmc-2018-0291
Abstract: AIM Identification of new antiproliferative compounds. METHODOLOGY Four series of compounds were synthesized by the Mitsunobu reaction. Their antiproliferative activity was studied against several cancer cells and a noncancerous fibroblast cell line. Their apoptotic activity… read more here.
Keywords: purine derivatives; derivatives heterocyclic; moieties related; heterocyclic moieties ... See more keywords