Synthesis of heterocyclic ring-fused analogs of HMG499 as novel degraders of HMG-CoA reductase that lower cholesterol.
Sign Up to like & getrecommendations! Published in 2022 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2022.114323
Abstract: HMG-CoA reductase (HMGCR) is the rate-limiting enzyme in cholesterol de novo biosynthesis and its degradation may bring therapeutic benefits for the treatment of cardiovascular disease (CVD) and nonalcoholic steatohepatitis (NASH). Before, we disclosed compound HMG499… read more here.
Keywords: heterocyclic ring; fused analogs; cholesterol; ring fused ... See more keywords
Tuning of Heterocyclic Ring in Para-Benzi Heterosapphyrins.
Sign Up to like & getrecommendations! Published in 2023 at "Organic letters"
DOI: 10.1021/acs.orglett.3c01371
Abstract: Three examples of moderately aromatic p-benzi dithiasapphyrin and p-benzi tellurathiasapphyrins have been synthesized by condensing p-benzithiophene diol with 16-thia/telluratripyrrane under acid-catalyzed reaction conditions. The X-ray structural analysis showed that the thiophene ring in p-benzi dithiasapphyrin… read more here.
Keywords: benzi dithiasapphyrin; benzi; benzi tellurathiasapphyrins; tuning heterocyclic ... See more keywords