Overall Survival in Men With Bone Metastases From Castration-Resistant Prostate Cancer Treated With Bone-Targeting Radioisotopes: A Meta-analysis of Individual Patient Data From Randomized Clinical Trials.
Sign Up to like & getrecommendations! Published in 2019 at "JAMA oncology"
DOI: 10.1001/jamaoncol.2019.4097
Abstract: Importance Both α-emitting and β-emitting bone-targeted radioisotopes (RIs) have been developed to treat men with metastatic castration-resistant prostate cancer (CRPC). Only 1 phase 3 randomized clinical trial has demonstrated an overall survival (OS) benefit from… read more here.
Keywords: trial; heterogeneity; prostate cancer; randomized clinical ... See more keywords
Genetic Liabilities Differentiating Bipolar Disorder, Schizophrenia, and Major Depressive Disorder, and Phenotypic Heterogeneity in Bipolar Disorder
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Psychiatry"
DOI: 10.1001/jamapsychiatry.2022.2594
Abstract: Key Points Question Are there etiological associations between clinical heterogeneity in participants with bipolar disorder and components of genetic liability that are shared between schizophrenia, bipolar disorder, and major depressive disorder and components that differentiate… read more here.
Keywords: heterogeneity; differentiating bipolar; bipolar disorder; depressive disorder ... See more keywords
Multiregion ultra‐deep sequencing reveals early intermixing and variable levels of intratumoral heterogeneity in colorectal cancer
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12012
Abstract: Intratumor heterogeneity (ITH) contributes to cancer progression and chemoresistance. We sought to comprehensively describe ITH of somatic mutations, copy number, and transcriptomic alterations involving clinically and biologically relevant gene pathways in colorectal cancer (CRC). We… read more here.
Keywords: ultra deep; deep sequencing; colorectal cancer; heterogeneity ... See more keywords
A pipeline for copy number profiling of single circulating tumor cells to assess intra-patient tumor heterogeneity.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular oncology"
DOI: 10.1002/1878-0261.13174
Abstract: Intra-patient tumor heterogeneity is likely a major determinant of clinical outcome in cancer patients. To assess heterogeneity in a minimally invasive manner, methods to perform single circulating tumor cell (CTC) genomics at high resolution are… read more here.
Keywords: tumor; patient tumor; heterogeneity; pipeline ... See more keywords
Development of an independent MU calculation software for radiotherapy treatments with stereotactic cones
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Applied Clinical Medical Physics"
DOI: 10.1002/acm2.13542
Abstract: Abstract Purpose Development of an independent MU calculator (StereoCalc) with and without heterogeneity corrections for stereotactic treatments, in a Varian TrueBeam STx LINAC using stereotactic cones, with flattening filter‐free photon energies. Methods Multiple depth curves… read more here.
Keywords: software; development independent; heterogeneity; stereotactic cones ... See more keywords
Reply to: No evidence supports genetic heterogeneity of neuronal intranuclear inclusion disease
Sign Up to like & getrecommendations! Published in 2020 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.51222
Abstract: We appreciate Li and colleagues’ interest in our work which did not identify associated NOTCH2NLC CGG expansion after screening a large pathologically confirmed cohort of European neuronal intranuclear inclusion disease (NIID) and additional cases with… read more here.
Keywords: genetic heterogeneity; heterogeneity; inclusion disease; intranuclear inclusion ... See more keywords
Deciphering the Heterogeneity Landscape of Mesenchymal Stem/Stromal Cell-Derived Extracellular Vesicles for Precise Selection in Translational Medicine.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202202453
Abstract: Owing to the low immunogenicity and high target affinities, mesenchymal stem/stromal cell-derived extracellular vesicles (MSC-EVs) have been considered promising therapeutics for disease treatments. However, MSC-EVs that are harvested from different tissues present unique biological features… read more here.
Keywords: msc evs; heterogeneity; medicine; stem stromal ... See more keywords
Outstanding Strengthening and Toughening Behavior of 3D-Printed Fiber-Reinforced Composites Designed by Biomimetic Interfacial Heterogeneity.
Sign Up to like & getrecommendations! Published in 2021 at "Advanced science"
DOI: 10.1002/advs.202103561
Abstract: 3D printing of fiber-reinforced composites is expected to be the forefront technology for the next-generation high-strength, high-toughness, and lightweight structural materials. The intrinsic architecture of 3D-printed composites closely represents biomimetic micro/macrofibril-like hierarchical structure composed of… read more here.
Keywords: heterogeneity; toughness; fiber reinforced; fiber ... See more keywords
Dissecting Heterogeneity Reveals a Unique BAMBIhighMFGE8high Subpopulation of Human UC‐MSCs
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202202510
Abstract: Mixed human umbilical cord‐derived mesenchymal stem cells (UC‐MSCs) are widely applied in clinical trials to treat various diseases due to their multipotent differentiation potential and immune regulatory activities. However, the lack of a clear understanding… read more here.
Keywords: heterogeneity; dissecting heterogeneity; reveals unique; human mscs ... See more keywords
Single‐Cell and Spatial Transcriptomics Decodes Wharton's Jelly‐Derived Mesenchymal Stem Cells Heterogeneity and a Subpopulation with Wound Repair Signatures
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202204786
Abstract: The highly heterogeneous characteristics of Wharton's jelly mesenchymal stem cells (WJ‐MSCs) may be responsible for the poor clinical outcomes and poor reproducibility of treatments based on WJ‐MSCs. Exploration of WJ‐MSC heterogeneity with multimodal single‐cell technologies… read more here.
Keywords: subpopulation; cell; heterogeneity; single cell ... See more keywords
Within-plant heterogeneity in fecundity and herbivory induced by localized DNA hypomethylation in the perennial herb Helleborus foetidus.
Sign Up to like & getrecommendations! Published in 2019 at "American journal of botany"
DOI: 10.1002/ajb2.1291
Abstract: PREMISE Phenotypic heterogeneity of reiterated, homologous structures produced by individual plants has ecological consequences for plants and their animal consumers. This paper examines experimentally the epigenetic mosaicism hypothesis, which postulates that within-plant variation in traits… read more here.
Keywords: seed; dna; within plant; heterogeneity ... See more keywords