Genetic Heterogeneity of BRAF Fusion Kinases in Melanoma Affects Drug Responses.
Sign Up to like & getrecommendations! Published in 2019 at "Cell reports"
DOI: 10.1016/j.celrep.2019.09.009
Abstract: BRAF fusions are detected in numerous neoplasms, but their clinical management remains unresolved. We identified six melanoma lines harboring BRAF fusions representative of the clinical cases reported in the literature. Their unexpected heterogeneous responses to… read more here.
Keywords: genetic heterogeneity; braf fusions; braf; fusion kinases ... See more keywords
Intra-patient Heterogeneity of BRAF and NRAS Molecular Alterations in Primary Melanoma and Metastases.
Sign Up to like & getrecommendations! Published in 2019 at "Acta dermato-venereologica"
DOI: 10.2340/00015555-3382
Abstract: Mutations in MAPK signalling genes are driver events in melanoma, and have therapeutic relevance in the metastatic and adjuvant setting. This study evaluated the intra-patient heterogeneity of BRAF, NRAS and c-KIT mutational status between 30… read more here.
Keywords: braf nras; patient heterogeneity; heterogeneity braf; intra patient ... See more keywords