Heterogeneity in RAS mutations: One size does not fit all
Sign Up to like & getrecommendations! Published in 2022 at "Science Signaling"
DOI: 10.1126/scisignal.adc9816
Abstract: Although oncogenic driver mutations in RAS occur in 20% of cancers, heterogeneity in the biologic outputs of different RAS mutants has hampered efforts to develop effective treatments for RAS-mutated cancers. In this issue of Science… read more here.
Keywords: heterogeneity; ras mutations; heterogeneity ras; mutations one ... See more keywords
Intratumorous heterogeneity for RAS mutations in a treatment-naïve colorectal tumour
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Pathology"
DOI: 10.1136/jclinpath-2017-204327
Abstract: Activating mutations in KRAS and NRAS genes in patients with colorectal cancer (CRC) are associated with a lack of response to treatment with anti-epidermal growth factor receptor (EGFR) therapies. Mutations in these genes are thought… read more here.
Keywords: treatment; ras mutations; intratumorous heterogeneity; colorectal tumour ... See more keywords