Sensitivity to food and cocaine cues are independent traits in a large sample of heterogeneous stock rats
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DOI: 10.1038/s41598-020-80798-w
Abstract: Sensitivity to cocaine and its associated stimuli (“cues”) are important factors in the development and maintenance of addiction. Rodent studies suggest that this sensitivity is related, in part, to the propensity to attribute incentive salience… read more here.
Keywords: heterogeneous stock; stock rats; cocaine; food ... See more keywords
Genetic polymorphisms and their association with brain and behavioural measures in heterogeneous stock mice
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DOI: 10.1038/srep41204
Abstract: Although the search for quantitative trait loci for behaviour remains a considerable challenge, the complicated genetic architecture of quantitative traits is beginning to be understood. The current project utilised heterogeneous stock (HS) male mice (n = 580)… read more here.
Keywords: genetic polymorphisms; association; mice; heterogeneous stock ... See more keywords
The regulatory landscape of multiple brain regions in outbred heterogeneous stock rats
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DOI: 10.1093/nar/gkac912
Abstract: Heterogeneous Stock (HS) rats are a genetically diverse outbred rat population that is widely used for studying genetics of behavioral and physiological traits. Mapping Quantitative Trait Loci (QTL) associated with transcriptional changes would help to… read more here.
Keywords: brain regions; regulatory landscape; brain; heterogeneous stock ... See more keywords
Genome-Wide Association Study on Three Behaviors Tested in an Open Field in Heterogeneous Stock Rats Identifies Multiple Loci Implicated in Psychiatric Disorders
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DOI: 10.3389/fpsyt.2022.790566
Abstract: Many personality traits are influenced by genetic factors. Rodents models provide an efficient system for analyzing genetic contribution to these traits. Using 1,246 adolescent heterogeneous stock (HS) male and female rats, we conducted a genome-wide… read more here.
Keywords: open field; psychiatric disorders; genome wide; association study ... See more keywords