Reversible compromise of physiological resilience by accumulation of heteroplasmic mtDNA mutations.
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DOI: 10.1126/science.adk7978
Abstract: Somatically acquired mitochondrial DNA mutations accumulate with age, but the mechanisms and consequences are poorly understood. Here we show that transient injuries induce a burst of persistent mtDNA mutations that impair resilience to future injuries.… read more here.
Keywords: physiological resilience; heteroplasmic mtdna; mtdna mutations; reversible compromise ... See more keywords