Mitochondrial DNA m.13514G>A heteroplasmy is associated with depressive symptoms in the elderly
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Geriatric Psychiatry"
DOI: 10.1002/gps.4928
Abstract: Mitochondrial DNA (mtDNA) heteroplasmy is a mixture of normal and mutated mtDNA molecules in a cell. High levels of heteroplasmy at several mtDNA sites in complex I lead to inherited neurological neurologic diseases and brain… read more here.
Keywords: associated depressive; depressive symptoms; symptoms elderly; heteroplasmy ... See more keywords
Impact of measuring heteroplasmy of a pathogenic mitochondrial DNA variant at the single‐cell level in individuals with mitochondrial disease
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Inherited Metabolic Disease"
DOI: 10.1002/jimd.12547
Abstract: Pathogenic mitochondrial DNA heteroplasmy has mainly been assessed with bulk sequencing in individuals with mitochondrial disease. However, the distribution of heteroplasmy at the single‐cell level in skin fibroblasts obtained from individuals, together with detailed clinical… read more here.
Keywords: cell level; single cell; heteroplasmy; disease ... See more keywords
Enhanced Manipulation of Human Mitochondrial DNA Heteroplasmy In Vitro Using Tunable mtZFN Technology.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8799-3_4
Abstract: As a platform capable of mtDNA heteroplasmy manipulation, mitochondrially targeted zinc-finger nuclease (mtZFN) technology holds significant potential for the future of mitochondrial genome engineering, in both laboratory and clinic. Recent work highlights the importance of… read more here.
Keywords: mtzfn technology; heteroplasmy; mtzfn; enhanced manipulation ... See more keywords
Comprehensive Quantification of the Modified Proteome Reveals Oxidative Heart Damage in Mitochondrial Heteroplasmy.
Sign Up to like & getrecommendations! Published in 2018 at "Cell reports"
DOI: 10.1016/j.celrep.2018.05.080
Abstract: Post-translational modifications hugely increase the functional diversity of proteomes. Recent algorithms based on ultratolerant database searching are forging a path to unbiased analysis of peptide modifications by shotgun mass spectrometry. However, these approaches identify only… read more here.
Keywords: heart; heteroplasmy; quantification modified; comprehensive quantification ... See more keywords
Detection of mitochondrial DNA variants at low level heteroplasmy in pediatric CNS and extra-CNS solid tumors with three different enrichment methods.
Sign Up to like & getrecommendations! Published in 2020 at "Mitochondrion"
DOI: 10.1016/j.mito.2020.01.006
Abstract: The mitochondrial genome is small, 16.5kb, and yet complex to study due to an abundance of mitochondria in any given cell or tissue. Mitochondrial DNA (mtDNA) mutations have been previously described in cancer, many of… read more here.
Keywords: enrichment; heteroplasmy; cns; cns extra ... See more keywords
Ancient hybridization and mtDNA introgression behind current paternal leakage and heteroplasmy in hybrid zones
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-55764-w
Abstract: Hybridization between heterospecific individuals has been documented as playing a direct role in promoting paternal leakage and mitochondrial heteroplasmy in both natural populations and laboratory conditions, by relaxing the egg-sperm recognition mechanisms. Here, we tested… read more here.
Keywords: mtdna introgression; heteroplasmy; paternal leakage;
Population-specific signatures of intra-individual mitochondrial DNA heteroplasmy and their potential evolutionary advantages
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-019-56918-6
Abstract: Heteroplasmy is the existence of more than one mitochondrial DNA (mtDNA) variant within a cell. The evolutionary mechanisms of heteroplasmy are not fully understood, despite being a very common phenomenon. Here we combined heteroplasmy measurements… read more here.
Keywords: mitochondrial dna; heteroplasmy; population; population specific ... See more keywords
Forensic evaluation of mitochondrial DNA heteroplasmy in Gujarat population, India
Sign Up to like & getrecommendations! Published in 2022 at "Annals of Human Biology"
DOI: 10.1080/03014460.2022.2144447
Abstract: Abstract Background Owing to its high copy number and its small size, mtDNA analysis is the most reliable choice when biological materials from crime scenes are degraded or have mixed STR profiles. Aim To examine… read more here.
Keywords: gujarat population; heteroplasmy; mitochondrial dna; population ... See more keywords
Natural Heteroplasmy and Mitochondrial Inheritance in Bivalve Molluscs.
Sign Up to like & getrecommendations! Published in 2019 at "Integrative and comparative biology"
DOI: 10.1093/icb/icz061
Abstract: Heteroplasmy is the presence of more than one type of mitochondrial genome within an individual, a condition commonly reported as unfavourable and affecting mitonuclear interactions. So far, no study has investigated heteroplasmy at protein level,… read more here.
Keywords: heteroplasmy mitochondrial; heteroplasmy; inheritance; biology ... See more keywords
Heteroplasmy and Patterns of Cytonuclear Linkage Disequilibrium in Wild Carrot.
Sign Up to like & getrecommendations! Published in 2019 at "Integrative and comparative biology"
DOI: 10.1093/icb/icz102
Abstract: Organellar genomes are considered to be strictly uniparentally-inherited. Uniparental inheritance allows for cytonuclear coevolution and the development of highly coordinated cytonuclear interactions. Yet, instances of biparental inheritance have been documented across eukaryotes. Biparental inheritance in… read more here.
Keywords: cytonuclear linkage; heteroplasmy; wild carrot; organellar genomes ... See more keywords
Quantitative haplotype-resolved analysis of mitochondrial DNA heteroplasmy in Human single oocytes, blastoids, and pluripotent stem cells
Sign Up to like & getrecommendations! Published in 2023 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkad209
Abstract: Abstract Maternal mitochondria are the sole source of mtDNA for every cell of the offspring. Heteroplasmic mtDNA mutations inherited from the oocyte are a common cause of metabolic diseases and associated with late-onset diseases. However,… read more here.
Keywords: pluripotent stem; analysis; mtdna; single oocytes ... See more keywords