Comparison of antimicrobial efficacy of eravacycline and tigecycline against clinical isolates of Streptococcus agalactiae in China: In vitro activity, heteroresistance, and cross-resistance.
Sign Up to like & getrecommendations! Published in 2020 at "Microbial pathogenesis"
DOI: 10.1016/j.micpath.2020.104502
Abstract: AIMS The aims of this study were to compare the antimicrobial efficacy of Eravacycline (Erava)versus tigecycline (Tig) in vitro against clinical isolates of S. agalactiae from China and further to evaluate the heteroresistance risk and… read more here.
Keywords: heteroresistance; isolates agalactiae; agalactiae china; resistance ... See more keywords
Carbapenem-resistant K. pneumoniae exhibiting clinically undetected amikacin and meropenem heteroresistance leads to treatment failure in a murine model of infection.
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DOI: 10.1016/j.micpath.2021.105162
Abstract: Heteroresistance is a poorly understood mechanism of resistance which refers to a phenomenon where there are different subpopulations of seemingly isogenic bacteria exhibit a range of susceptibilities to a particular antibiotic. In the current study,… read more here.
Keywords: heteroresistance; treatment failure; pneumoniae; amikacin meropenem ... See more keywords
Plasmonic Colloidosomes Coupled MALDI-TOF MS for Bacterial Heteroresistance Study at Single-Cell Level.
Sign Up to like & getrecommendations! Published in 2020 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.0c00494
Abstract: Antimicrobial resistance (AMR) is a long-term public health challenge worldwide, and it is increasingly recognized to be a heteroresistance phenomenon in an isogenic bacterial population. When the minority population of resistant bacteria with strong AMR… read more here.
Keywords: heteroresistance; study single; maldi tof; plasmonic colloidosomes ... See more keywords
Fluoroquinolone heteroresistance in Mycobacterium tuberculosis: detection by genotypic and phenotypic assays in experimentally mixed populations
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DOI: 10.1038/s41598-019-48289-9
Abstract: Heteroresistance - the simultaneous presence of drug-susceptible and -resistant organisms - is common in Mycobacterium tuberculosis. In this study, we aimed to determine the limit of detection (LOD) of genotypic assays to detect gatifloxacin-resistant mutants… read more here.
Keywords: heteroresistance; detection; tuberculosis; experimentally mixed ... See more keywords
Droplet-based digital antibiotic susceptibility screen reveals single-cell clonal heteroresistance in an isogenic bacterial population
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DOI: 10.1038/s41598-020-60381-z
Abstract: Since antibiotic resistance is a major threat to global health, recent observations that the traditional test of minimum inhibitory concentration (MIC) is not informative enough to guide effective antibiotic treatment are alarming. Bacterial heteroresistance, in… read more here.
Keywords: heteroresistance; single cell; isogenic bacterial; droplet based ... See more keywords
Evaluation of the impact of polyclonal infection and heteroresistance on treatment of tuberculosis patients
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DOI: 10.1038/srep41410
Abstract: Mixed strain infections of Mycobacterium tuberculosis make diagnosis, treatment, and control of tuberculosis (TB) more difficult. This study was aimed to evaluate the relationship between mixed infections, antibiotic resistance patterns and treatment of TB patients.… read more here.
Keywords: heteroresistance; mixed infections; treatment; infection ... See more keywords
Comment on: Bacteraemia with an MBL-producing Klebsiella pneumoniae: treatment and the potential role of cefiderocol heteroresistance
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Antimicrobial Chemotherapy"
DOI: 10.1093/jac/dkac277
Abstract: © The Author(s) 2022. Published by Oxford University Press on behalf of British Society for Antimicrobial Chemotherapy. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https:// creativecommons.org/licenses/by-nc/4.0/),… read more here.
Keywords: dilution; broth microdilution; pneumoniae; cefiderocol ... See more keywords
Heteroresistance to the model antimicrobial peptide polymyxin B in the emerging Neisseria meningitidis lineage 11.2 urethritis clade: mutations in the pilMNOPQ operon
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Microbiology"
DOI: 10.1111/mmi.14153
Abstract: Clusters of Neisseria meningitidis (Nm) urethritis among primarily heterosexual males in multiple US cities have been attributed to a unique non‐encapsulated meningococcal clade (the US Nm urethritis clade, US_NmUC) within the hypervirulent clonal complex 11.… read more here.
Keywords: heteroresistance; resistance; urethritis clade; neisseria meningitidis ... See more keywords
Heteroresistance and fungi
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DOI: 10.1111/myc.12639
Abstract: The concept of heteroresistance refers to the heterogeneous susceptibility to an antimicrobial drug in a microorganism population, meaning that some clones may be resistant and others are susceptible. This phenomenon has been widely studied in… read more here.
Keywords: heteroresistance; heteroresistance fungi;
Detection of Pyrazinamide Heteroresistance in Mycobacterium tuberculosis
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DOI: 10.1128/aac.00720-21
Abstract: Heteroresistance is defined as the coexistence of both susceptible and resistant bacteria in a bacterial population. Previously published data show that it may occur in 9 to 57% of Mycobacterium tuberculosis isolates for various drugs.… read more here.
Keywords: pza; drug; mycobacterium tuberculosis; heteroresistance ... See more keywords
Quantitative Pharmacodynamic Characterization of Resistance versus Heteroresistance of Colistin in E. coli Using a Semimechanistic Modeling of Killing Curves
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DOI: 10.1128/aac.00793-22
Abstract: Heteroresistance corresponds to the presence, in a bacterial isolate, of an initial small subpopulation of bacteria characterized by a significant reduction in their sensitivity to a given antibiotic. Mechanisms of heteroresistance versus resistance are poorly… read more here.
Keywords: mcr; mcr positive; colistin; resistance ... See more keywords