Human osteoprogenitor cells obtained from traumatic heterotopic ossification samples showed enhanced osteogenic differentiation potential and ERK/hedgehog signaling than that from normal bone
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DOI: 10.1002/iub.2670
Abstract: Traumatic heterotopic ossification (HO) refers to the abnormal ectopic osteogenesis following trauma, causing limb dysfunction and seriously lowering the life quality of patients. Aberrant osteogenic behavior of progenitor cells that ectopically accumulated within the soft… read more here.
Keywords: hedgehog signaling; heterotopic ossification; osteogenic differentiation; hedgehog ... See more keywords
Trauma-Induced Nanohydroxyapatite Deposition in Skeletal Muscle is Sufficient to Drive Heterotopic Ossification
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DOI: 10.1007/s00223-018-0502-5
Abstract: Heterotopic ossification (HO), or the pathologic formation of bone within soft tissues, is a significant complication following severe injuries as it impairs joint motion and function leading to loss of the ability to perform activities… read more here.
Keywords: skeletal muscle; heterotopic ossification; muscle; deposition ... See more keywords
Unintended fusion in cervical artificial disk replacement: a prospective study on heterotopic ossification, progression, and clinical outcome, with 5-year follow-up
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DOI: 10.1007/s00586-021-06722-6
Abstract: Heterotopic ossification (HO) may cause unintended fusion in artificial disk replacement (ADR), failing to preserve motion. The reported incidence of HO varies hugely. This study aimed to determine prevalence of HO, progression, predisposing factors to… read more here.
Keywords: heterotopic ossification; artificial disk; unintended fusion; progression ... See more keywords
The efficacy of a multimodal analgesia protocol in preventing heterotopic ossification after acetabular fractures surgery
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DOI: 10.1007/s11096-017-0476-9
Abstract: Background Heterotopic ossification (HO) after joint surgery is always a disturbing problem for patients and surgeons. Prophylaxis is the most effective therapy. Objective To assess the efficacy and safety of a multimodal analgesia protocol that… read more here.
Keywords: acetabular fractures; heterotopic ossification; multimodal analgesia; group ... See more keywords
Delivery vehicle effects on bone regeneration and heterotopic ossification induced by high dose BMP-2.
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DOI: 10.1016/j.actbio.2016.12.012
Abstract: Bone morphogenetic protein-2 (BMP-2), delivered on absorbable collagen sponge, is frequently used to treat bone defects. However, supraphysiological BMP-2 doses are common and often associated with complications such as heterotopic ossification and inflammation, causing pain… read more here.
Keywords: heterotopic ossification; bmp; bone regeneration; delivery ... See more keywords
Sustained local ionic homeostatic imbalance caused by calcification modulates inflammation to trigger heterotopic ossification.
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DOI: 10.1016/j.actbio.2022.03.057
Abstract: Heterotopic ossification (HO) is a condition triggered by an injury leading to the formation of mature lamellar bone in extraskeletal soft tissues. Despite being a frequent complication of orthopedic and trauma surgery, brain and spinal… read more here.
Keywords: formation; calcification; heterotopic ossification; bone ... See more keywords
A Retrospective Analysis of 287 Patients Undergoing Prophylactic Radiation Therapy for the Prevention of Heterotopic Ossification
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DOI: 10.1016/j.adro.2020.11.010
Abstract: Purpose Heterotopic ossification (HO) is a potentially disabling disorder of ectopic bone formation secondary to orthopedic surgery or trauma. In this retrospective analysis we evaluated the outcomes of patients who received radiation therapy (RT) for… read more here.
Keywords: heterotopic ossification; radiation therapy; analysis; 287 patients ... See more keywords
Appropriate excision time of heterotopic ossification in elbow caused by trauma
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DOI: 10.1016/j.aott.2017.11.008
Abstract: Objective The aim of this study was to investigate the optimal timing for the resection of heterotopic ossification (HO) of the elbow. Methods We retrospectively reviewed 42 patients who were treated operatively for heterotopic ossification… read more here.
Keywords: heterotopic ossification; ossification elbow; time; excision ... See more keywords
Severe heterotopic ossification and stiffness after revision knee surgery for a periprosthetic fracture
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DOI: 10.1016/j.artd.2016.11.001
Abstract: Although heterotopic ossification (HO) after total hip arthroplasty has been very well described as a cause of disability, much less was written on clinical dysfunction of HO after total knee arthroplasty (TKA). To the extent… read more here.
Keywords: heterotopic ossification; surgery; revision; knee ... See more keywords
Heterotopic ossification: Mechanistic insights and clinical challenges.
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DOI: 10.1016/j.bone.2017.08.025
Abstract: Bone formation is exquisitely controlled both spatially and temporally. Heterotopic ossification (HO) is pathological bone formation in soft tissues that often leads to deleterious outcomes. Inherited genetic forms of HO can be life-threatening and can… read more here.
Keywords: heterotopic ossification; insights clinical; ossification mechanistic; ossification ... See more keywords
A case report of mesenteric heterotopic ossification: Histopathologic and genetic findings.
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DOI: 10.1016/j.bone.2018.01.006
Abstract: Mesenteric heterotopic ossification (MHO) is very rare and occurs in mid- to late-adulthood, usually in the context of prior abdominal surgery. The mechanisms of MHO are unknown. Here we describe the case of a 72-year-old… read more here.
Keywords: heterotopic ossification; report mesenteric; mesenteric heterotopic; case report ... See more keywords