Association of Klotho Protein Levels and KL-VS Heterozygosity With Alzheimer Disease and Amyloid and Tau Burden
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2022.43232
Abstract: Key Points Question What is the association between Klotho protein levels in cerebrospinal fluid (CSF) and plasma, heterozygosity status of the KL-VS haplotype, and amyloid and tau burden among cognitively healthy controls and patients with… read more here.
Keywords: amyloid tau; heterozygosity; protein levels; klotho protein ... See more keywords
Primary mediastinal large B‐cell lymphoma is characterized by large‐scale copy‐neutral loss of heterozygosity
Sign Up to like & getrecommendations! Published in 2022 at "Genes"
DOI: 10.1002/gcc.23069
Abstract: Development of primary mediastinal B‐cell lymphoma (PMBL) is driven by cumulative genomic aberrations. We discovered a unique copy‐neutral loss of heterozygosity (CN‐LOH) landscape of PMBL which distinguishes this tumor from other B‐cell malignancies, including the… read more here.
Keywords: pmbl; cell; cell lymphoma; large cell ... See more keywords
Gain and Loss of Heterozygosity in the Genome of the Asexual Nematode Halicephalobus mephisto
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Molecular Evolution"
DOI: 10.1007/s00239-025-10259-3
Abstract: Asexual reproduction often leads to loss of genetic diversity, but several mechanisms have evolved to maintain heterozygosity. The subterrestrial nematode, Halicephalobus mephisto, reproduces parthenogenetically, and here, we investigate how its genetic diversity -\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym}… read more here.
Keywords: loss; history; loss heterozygosity; heterozygosity ... See more keywords
On the heterozygosity of an admixed population.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of mathematical biology"
DOI: 10.1007/s00285-020-01531-9
Abstract: In this study, we consider admixed populations through their expected heterozygosity, a measure of genetic diversity. A population is termed admixed if its members possess recent ancestry from two or more separate sources. As a… read more here.
Keywords: admixed population; source populations; source; heterozygosity ... See more keywords
Individual heterozygosity and fitness in bottlenecked populations during early colonisation
Sign Up to like & getrecommendations! Published in 2025 at "Biological Invasions"
DOI: 10.1007/s10530-025-03571-y
Abstract: Some populations of alien species, established by a small number of individuals, spread rapidly. This is the ‘genetic paradox of invasions’ as they must overcome the negative effects of the demographic bottleneck during the establishment… read more here.
Keywords: fitness; individual heterozygosity; size; colonisation ... See more keywords
Effective population size and heterozygosity-fitness correlations in a population of the Mediterranean lagoon ecotype of long-snouted seahorse Hippocampus guttulatus
Sign Up to like & getrecommendations! Published in 2019 at "Conservation Genetics"
DOI: 10.1007/s10592-019-01210-3
Abstract: The management of endangered species is complicated in the marine environment owing to difficulties to directly access, track and monitor in situ. Population genetics provide a genuine alternative to estimate population size and inbreeding using… read more here.
Keywords: long snouted; heterozygosity; effective population; population size ... See more keywords
Influence of heterozygosity and competition on morphological tree characteristics of Quercus rubra L.: a new single-tree based approach
Sign Up to like & getrecommendations! Published in 2020 at "New Forests"
DOI: 10.1007/s11056-020-09814-1
Abstract: In Europe, the non-native Northern red oak ( Quercus rubra L.) is widely recommended for future cultivation. However, outside its natural range, Northern red oak has to date been insufficiently studied both in terms of… read more here.
Keywords: tree; heterozygosity; red oak; competition ... See more keywords
Genetic diversity and mate selection in a reintroduced population of gray wolves
Sign Up to like & getrecommendations! Published in 2022 at "Scientific Reports"
DOI: 10.1038/s41598-021-04449-4
Abstract: The genetic composition of an individual can markedly affect its survival, reproduction, and ultimately fitness. As some wildlife populations become smaller, conserving genetic diversity will be a conservation challenge. Many imperiled species are already supported… read more here.
Keywords: diversity; population gray; heterozygosity; gray wolves ... See more keywords
Genome wide association studies in yam reveal the challenge of high heterozygosity
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-025-10344-z
Abstract: Yam (Dioscorea spp.) is a herbaceous vine crop valued for its starchy tubers, which are rich in essential nutrients. Its genome is highly heterozygous, contributing to considerable genetic diversity and adaptability. Understanding the polymorphism information… read more here.
Keywords: genome wide; pic; fresh tuber; wide association ... See more keywords
Pten heterozygosity restores neuronal morphology in fragile X syndrome mice
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2109448119
Abstract: Significance Phosphatase and tensin homolog protein (PTEN) and fragile X mental retardation protein (FMRP) play a vital role in neuronal development and function. This work provides new evidence for the genetic interaction of Pten and… read more here.
Keywords: heterozygosity restores; pten heterozygosity; neuronal morphology; pten fmr1 ... See more keywords
Genomic HLA heterozygosity as a predictive marker for survival in lung cancer patients post immunotherapy
Sign Up to like & getrecommendations! Published in 2019 at "Annals of Oncology"
DOI: 10.1093/annonc/mdz446.013
Abstract: Abstract Background We aimed to assess the role of genomic HLA-I/II heterozygosity in the overall survival benefit in patients with unresectable locally advanced, metastatic non-small lung cancer treated by PD1/L1 inhibitors. Methods We collected blood… read more here.
Keywords: hla heterozygosity; heterozygosity; lung cancer; hla ... See more keywords