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Published in 2022 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2022.43232
Abstract: Key Points Question What is the association between Klotho protein levels in cerebrospinal fluid (CSF) and plasma, heterozygosity status of the KL-VS haplotype, and amyloid and tau burden among cognitively healthy controls and patients with…
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Keywords:
amyloid tau;
heterozygosity;
protein levels;
klotho protein ... See more keywords
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Published in 2022 at "Genes"
DOI: 10.1002/gcc.23069
Abstract: Development of primary mediastinal B‐cell lymphoma (PMBL) is driven by cumulative genomic aberrations. We discovered a unique copy‐neutral loss of heterozygosity (CN‐LOH) landscape of PMBL which distinguishes this tumor from other B‐cell malignancies, including the…
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Keywords:
pmbl;
cell;
cell lymphoma;
large cell ... See more keywords
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Published in 2020 at "Journal of mathematical biology"
DOI: 10.1007/s00285-020-01531-9
Abstract: In this study, we consider admixed populations through their expected heterozygosity, a measure of genetic diversity. A population is termed admixed if its members possess recent ancestry from two or more separate sources. As a…
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Keywords:
admixed population;
source populations;
source;
heterozygosity ... See more keywords
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Published in 2019 at "Conservation Genetics"
DOI: 10.1007/s10592-019-01210-3
Abstract: The management of endangered species is complicated in the marine environment owing to difficulties to directly access, track and monitor in situ. Population genetics provide a genuine alternative to estimate population size and inbreeding using…
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Keywords:
long snouted;
heterozygosity;
effective population;
population size ... See more keywords
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Published in 2020 at "New Forests"
DOI: 10.1007/s11056-020-09814-1
Abstract: In Europe, the non-native Northern red oak ( Quercus rubra L.) is widely recommended for future cultivation. However, outside its natural range, Northern red oak has to date been insufficiently studied both in terms of…
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Keywords:
tree;
heterozygosity;
red oak;
competition ... See more keywords
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Published in 2022 at "Scientific Reports"
DOI: 10.1038/s41598-021-04449-4
Abstract: The genetic composition of an individual can markedly affect its survival, reproduction, and ultimately fitness. As some wildlife populations become smaller, conserving genetic diversity will be a conservation challenge. Many imperiled species are already supported…
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Keywords:
diversity;
population gray;
heterozygosity;
gray wolves ... See more keywords
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Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2109448119
Abstract: Significance Phosphatase and tensin homolog protein (PTEN) and fragile X mental retardation protein (FMRP) play a vital role in neuronal development and function. This work provides new evidence for the genetic interaction of Pten and…
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Keywords:
heterozygosity restores;
pten heterozygosity;
neuronal morphology;
pten fmr1 ... See more keywords
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Published in 2019 at "Annals of Oncology"
DOI: 10.1093/annonc/mdz446.013
Abstract: Abstract Background We aimed to assess the role of genomic HLA-I/II heterozygosity in the overall survival benefit in patients with unresectable locally advanced, metastatic non-small lung cancer treated by PD1/L1 inhibitors. Methods We collected blood…
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Keywords:
hla heterozygosity;
heterozygosity;
lung cancer;
hla ... See more keywords
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Published in 2022 at "Genetics"
DOI: 10.1093/genetics/iyac083
Abstract: Many studies have quantified the distribution of heterozygosity and relatedness in natural populations, but few have examined the demographic processes driving these patterns. In this study, we take a novel approach by studying how population…
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Keywords:
heterozygosity;
distribution heterozygosity;
distribution;
population structure ... See more keywords
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Published in 2018 at "Journal of Economic Entomology"
DOI: 10.1093/jee/toy050
Abstract: Abstract In order to understand the population genetic diversity and structure of Spodoptera exigua (Hübner) (Lepidoptera: Noctuidae), a serious pest of sugar beet in Iran and the world, we genotyped 133 individuals from seven regions…
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Keywords:
heterozygosity;
lepidoptera;
lepidoptera noctuidae;
genetic variation ... See more keywords
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Published in 2017 at "Molecular Biology and Evolution"
DOI: 10.1093/molbev/msx098
Abstract: Abstract Hybridization is often considered maladaptive, but sometimes hybrids can invade new ecological niches and adapt to novel or stressful environments better than their parents. The genomic changes that occur following hybridization that facilitate genome…
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Keywords:
hybrid yeast;
heterozygosity;
loss heterozygosity;
adaptation ... See more keywords