Heterozygous APC germline mutations impart predisposition to colorectal cancer
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DOI: 10.1038/s41598-021-84564-4
Abstract: Familial adenomatous polyposis (FAP) is an inherited syndrome caused by a heterozygous adenomatous polyposis coli (APC) germline mutation, associated with a profound lifetime risk for colorectal cancer. While it is well accepted that tumorigenic transformation… read more here.
Keywords: germline mutations; fap; colon; heterozygous apc ... See more keywords